Evidence for distinct genetic effects associated with response to 35% CO₂.
Evidence for distinct genetic effects associated with response to 35% CO₂.
复制标题
DOI：
10.1002/da.22038
复制
发表时间：
2013-03
影响因子：
7.4
通讯作者：
Battaglia, Marco
中科院分区：
文献类型：
--
作者：
Roberson-Nay, Roxann;Moruzzi, Sara;Ogliari, Anna;Pezzica, Elettra;Tambs, Kristian;Kendler, Kenneth S.;Battaglia, Marco
二氧化碳 (CO2) 过敏症代表对呼吸富含二氧化碳的空气的个体差异反应。有惊恐发作或惊恐障碍病史的人特别容易出现焦虑反应，这表明二氧化碳超敏反应是恐慌谱系脆弱性的一个强有力的风险标志。来自挪威 NIPH 心理健康研究的双胞胎 (n = 346) 在肺活量吸入 35% CO2 空气前后以及吸入普通空气前后完成了焦虑测量。研究了关于 CO2 过敏遗传因素的三个假设：(1) 一组遗传风险因素在接触 CO2 之前影响焦虑，并且这些相同的基因构成了对 CO2 反应焦虑的唯一遗传影响，(2) 对 CO2 反应前焦虑的遗传影响完全不同于对接触 CO2 反应焦虑的遗传影响（即新的遗传效应），以及 (3) CO2 前焦虑影响对 CO2 反应的焦虑以及被激活的独特遗传因素通过呼吸刺激。我们的结果支持后一种对 35% CO2 反应的假设，附加遗传和独特的环境因素最适合数据。观察到新的遗传效应的证据，解释了 35% CO2 焦虑反应中 20% 的独特差异。对于定期空气后的焦虑评级，没有观察到新的遗传效应，而只有定期空气前的焦虑评级才能解释这一结果的显着差异。这些数据表明，存在与 35% CO2 呼吸刺激反应相关的独特遗传因素。
Carbon dioxide (CO2) hypersensitivity represents an individual difference response to breathing CO2 enriched air. People with a history of panic attacks or panic disorder are particularly prone to anxious response, suggesting that CO2 hypersensitivity is a robust risk marker of panic spectrum vulnerability. Twin pairs (n = 346) from the general population-based Norwegian NIPH Mental Health Study completed a measure of anxiety before and after vital capacity inhalation of 35% CO2 air and before and after inhalation of regular air. Three hypotheses regarding genetic factors for CO2 hypersensitivity were examined: (1) a single set of genetic risk factors impacts anxiety before exposure to CO2 and these same genes constitute the only genetic influences on anxiety in response to CO2, (2) the genetic effects on pre-CO2 anxiety are entirely different from the genetic effects on anxiety in response to exposure to CO2 (i.e., new genetic effects), and (3) pre-CO2 anxiety influences anxiety in response to CO2 as well as unique genetic factors that become activated by respiratory stimulation. Our results support the latter hypothesis for response to 35% CO2, with additive genetic and unique environmental factors best fitting the data. Evidence of new genetic effects was observed, accounting for 20% unique variance in post 35% CO2 anxiety response. New genetic effects were not observed for anxiety ratings made post regular air where only preregular air anxiety ratings explained significant variance in this outcome. These data suggest that there are distinct genetic factors associated with responsivity to respiratory stimulation via 35% CO2.
登录
查看更多内容
影响因子：
11.3
作者：
GRIEZ, E;DELOOF, C;LOUSBERG, H
通讯作者：
LOUSBERG, H
影响因子：
4.8
作者：
Battaglia, Marco;Ogliari, Anna;Tambs, Kristian
通讯作者：
Tambs, Kristian
影响因子：
22.8
作者：
Ogliari, Anna;Tambs, Kristian;Battaglia, Marco
通讯作者：
Battaglia, Marco
影响因子：
10.6
作者：
GORMAN, JM;PAPP, LA;JORDAN, F
通讯作者：
JORDAN, F
影响因子：
3
作者：
AKAIKE, H
通讯作者：
AKAIKE, H