Relationships between objective sleep parameters and inflammatory biomarkers in pregnancy.
Relationships between objective sleep parameters and inflammatory biomarkers in pregnancy.
复制标题
DOI：
10.1111/nyas.14375
复制
发表时间：
2020-08
影响因子：
5.2
通讯作者：
Izci-Balserak B
中科院分区：
文献类型：
--
作者：
Zhu B;Bronas UG;Carley DW;Lee K;Steffen A;Kapella MC;Izci-Balserak B
我们研究了怀孕后期睡眠和炎症生物标志物之间的关系。74名女性接受了多导睡眠图的夜间睡眠评估。分别于睡前和清醒后1 h内采血，测定C反应蛋白（CRP）、白细胞介素（IL）-6和IL-6可溶性受体。睡眠参数包括表征睡眠结构和睡眠连续性的变量。参与者年龄为32.2（SD = 4.1）岁，平均孕龄为32.8（3.5）周。控制协变量后，夜间CRP与N3睡眠呈负相关（β =-0.30，P = 0.010）。N3睡眠也与早晨CRP呈负相关（β =-0.26，P = 0.036），较高的N3睡眠百分比与较低的早晨CRP水平相关。N2期睡眠与晨起CRP呈显著正相关（β = 0.23，P = 0.065）。N1期睡眠与早晨IL-6相关（β = 0.28，P = 0.021），较高的N1期睡眠百分比与较高的早晨IL-6相关。在早晨炎症生物标志物和睡眠连续性参数之间没有发现显著的关联。总之，轻度睡眠增加与炎症生物标志物增加相关，而深度睡眠增加与炎症生物标志物减少相关。这些发现进一步支持了怀孕后期睡眠与免疫系统之间的相互作用。我们研究了怀孕后期睡眠和炎症生物标志物之间的关系。74名女性接受了多导睡眠图的夜间睡眠评估。在早晨炎症生物标志物和睡眠连续性参数之间没有发现显著的关联。总之，轻度睡眠增加与炎症生物标志物增加相关，而深度睡眠增加与炎症生物标志物减少相关。这些发现进一步支持了怀孕后期睡眠和免疫系统之间的相互作用。
We examined the relationships between sleep and inflammatory biomarkers during late pregnancy. Seventy-four women underwent an overnight sleep assessment by polysomnography. Blood samples were collected before bedtime and again within 1 h upon awakening to measure C-reactive protein (CRP), interleukin (IL)-6, and IL-6 soluble receptor. Sleep parameters included variables characterizing sleep architecture and sleep continuity. The participants were 32.2 (SD = 4.1) years old and the average gestational age was 32.8 (3.5) weeks. Controlling for covariates, evening CRP was negatively associated with N3 sleep (β = −0.30, P = 0.010). N3 sleep was also negatively associated with morning CRP (β = −0.26, P = 0.036), with a higher percentage of N3 sleep associated with a lower level of morning CRP. Contrarily, there was a tendency for a positive association between stage N2 sleep and morning CRP (β = 0.23, P = 0.065). Stage N1 sleep was associated with morning IL-6 (β = 0.28, P = 0.021), with a higher percentage of N1 sleep associated with a higher morning IL-6. No significant associations were found between morning inflammatory biomarkers and sleep continuity parameters. In conclusion, increased light sleep was associated with increased inflammatory biomarkers, whereas more deep sleep was associated with decreased inflammatory biomarkers. These findings further support the interactions between sleep and the immune system during late pregnancy. We examined the relationships between sleep and inflammatory biomarkers during late pregnancy. Seventy-four women underwent an overnight sleep assessment by polysomnography. No significant associations were found between morning inflammatory biomarkers and sleep continuity parameters. In conclusion, increased light sleep was associated with increased inflammatory biomarkers, whereas more deep sleep was associated with decreased inflammatory biomarkers. These findings further support the interactions between sleep and the immune system during late pregnancy.
登录
查看更多内容
影响因子：
3.4
作者：
Holingue C;Owusu JT;Feder KA;Spira AP
通讯作者：
Spira AP
影响因子：
15.1
作者：
Burgos, I;Richter, L;Riemann, D
通讯作者：
Riemann, D
影响因子：
5.6
作者：
Abell SK;De Courten B;Boyle JA;Teede HJ
通讯作者：
Teede HJ
影响因子：
4.8
作者：
Benedict, Christian;Scheller, Juergen;Marshall, Lisa
通讯作者：
Marshall, Lisa
影响因子：
3.7
作者：
Agorastos, Agorastos;Hauger, Richard L.;Baker, Dewleen G.
通讯作者：
Baker, Dewleen G.