The Oral Microbiome Bank of China.

The Oral Microbiome Bank of China.
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中国口腔微生物库

DOI:
10.1038/s41368-018-0018-x
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发表时间:
2018-05-03
影响因子:
14.9
通讯作者:
Ga L
Ga L
中科院分区:
医学1区
文献类型:
--
作者:
Xian P;Xuedong Z;Xin X;Yuqing L;Yan L;Jiyao L;Xiaoquan S;Shi H;Jian X;Ga L

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人类微生物组计划(HMP)促进了对人类口腔微生物的进一步了解。然而,对人类口腔微生物群的研究却没有肠道微生物群的研究取得那么大的进展。目前,口腔微生物群与口腔疾病之间的因果关系尚不清楚,对口腔微生物群与人类全身性疾病之间的联系知之甚少。为了进一步了解口腔微生物群在口腔疾病和全身性疾病中的作用,美国建立了人类口腔微生物群数据库(HOMD)。HOMD包括13门619个分类群,大部分微生物来自美洲种群。由于微生物组的个体差异,HOMD并不能反映中国人口腔微生物的状况。为此,我们建立了一个新的口腔微生物组数据库——中国口腔微生物组库(OMBC, http://www.sklod.org/ombc)。目前,OMBC包括289种细菌菌株和720个中国人群临床样本的信息,以及实验室和临床信息。OMBC是第一个与中国相关的微生物组的精心描述;它为研究口腔微生物组在健康和疾病中的作用提供了工具,并将为未来的口腔微生物研究提供丰富的数据和菌株信息。
The human microbiome project (HMP) promoted further understanding of human oral microbes. However, research on the human oral microbiota has not made as much progress as research on the gut microbiota. Currently, the causal relationship between the oral microbiota and oral diseases remains unclear, and little is known about the link between the oral microbiota and human systemic diseases. To further understand the contribution of the oral microbiota in oral diseases and systemic diseases, a Human Oral Microbiome Database (HOMD) was established in the US. The HOMD includes 619 taxa in 13 phyla, and most of the microorganisms are from American populations. Due to individual differences in the microbiome, the HOMD does not reflect the Chinese oral microbial status. Herein, we established a new oral microbiome database—the Oral Microbiome Bank of China (OMBC, http://www.sklod.org/ombc). Currently, the OMBC includes information on 289 bacterial strains and 720 clinical samples from the Chinese population, along with lab and clinical information. The OMBC is the first curated description of a Chinese-associated microbiome; it provides tools for use in investigating the role of the oral microbiome in health and diseases, and will give the community abundant data and strain information for future oral microbial studies.
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