Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.
Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults.
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DOI：
10.1371/journal.pone.0093545
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Iemitsu M
中科院分区：
文献类型：
--
作者：
Fujie S;Sato K;Miyamoto-Mikami E;Hasegawa N;Fujita S;Sanada K;Hamaoka T;Iemitsu M
有规律的运动可以减少由衰老引起的动脉硬化的恶化，增加一氧化氮（NO）的产生参与了这一作用。Apelin调节内皮细胞NO合成酶，促进NO生成。然而，有氧运动训练对健康中老年人循环apelin水平的影响尚不清楚。因此，本研究旨在阐明有规律的有氧运动对中老年人群中apelin浓度的影响。34名健康中老年受试者（67.0±1.3岁）随机分为运动干预组和久坐对照组。训练组完成为期8周的有氧运动训练（60-70%峰值摄氧量[vo2峰值]，每次45分钟，每周3天）。在干预前后，我们评估了血浆apelin和亚硝酸盐/硝酸盐（NOx）浓度、vo2峰和动脉僵硬指数。训练组干预后VO2peak显著升高，颈动脉β-僵硬度显著降低（P<0.05）。干预后训练组血浆apelin和NOx水平显著升高（P<0.05）。此外，血浆apelin水平、颈动脉β-硬度（r = - 0.508, P = 0.032）和血浆NOx水平（r = 0.494, P = 0.037）与训练效果存在相关性。相比之下，在对照组中，这些参数都没有显著变化。这些结果表明，血浆内皮蛋白水平的升高可能与运动训练引起的中老年人动脉僵硬度的变化有关。
Aging-induced deterioration of arterial stiffness is decreased by regular exercise, and increased nitric oxide (NO) production participates in this effect. Apelin regulates endothelial NO synthase in endothelial cells, promoting NO production. However, the effect of aerobic exercise training on circulating apelin levels in healthy middle-aged and older adults remains unknown. Accordingly, this study aimed to clarify the effects of regular aerobic exercise on apelin concentrations in middle-aged and older adults. Thirty-four healthy middle-aged and older subjects (67.0 ± 1.3 years) were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60–70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). Before and after the intervention, we evaluated plasma apelin and nitrite/nitrate (NOx) concentrations, VO2peak, and arterial stiffness index. In the training group, VO2peak was significantly increased, and carotid β-stiffness was significantly decreased, after the intervention (P<0.05). Moreover, plasma apelin and NOx levels were significantly increased in the training group after the intervention (P<0.05). Additionally, there was a correlation between the training effects of plasma apelin levels and carotidβ-stiffness (r = −0.508, P = 0.032) and plasma NOx levels (r = 0.494, P = 0.037). By contrast, none of these parameters changed significantly in the control group. These results suggest that the increased in plasma apelin levels may be associated with exercise training-induced alternation of arterial stiffness in middle-aged and older adults.
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影响因子：
8.7
作者：
Tanaka, H;DeSouza, CA;Seals, DR
通讯作者：
Seals, DR
DOI：
10.1006/bbrc.1998.9489
发表时间：
1998-10-20
影响因子：
3.1
作者：
Tatemoto, K;Hosoya, M;Fujino, M
通讯作者：
Fujino, M
影响因子：
8.3
作者：
Blacher, J;Asmar, R;Safar, ME
通讯作者：
Safar, ME
影响因子：
--
作者：
Tatemoto, K;Takayama, K;Fujimiya, M
通讯作者：
Fujimiya, M
影响因子：
5.4
作者：
Maeda, S;Tanabe, T;Matsuda, M
通讯作者：
Matsuda, M