The plate-to-rod transition in trabecular bone loss is elusive.
The plate-to-rod transition in trabecular bone loss is elusive.
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DOI：
10.1098/rsos.201401
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发表时间：
2021-06-09
影响因子：
3.5
通讯作者：
Doube M
中科院分区：
文献类型：
--
作者：
Felder AA;Monzem S;De Souza R;Javaheri B;Mills D;Boyde A;Doube M
小梁微结构的改变是我们了解骨质疏松症的关键。先前对结构模型指数（SMI）测量的研究已经得出结论，疾病进展需要小梁骨从板状到棒状的转变，但SMI严重受骨体积分数的影响。作为SMI的替代方案，我们提出椭球因子（EF）作为板状和杆状极值之间局部小梁形状的连续测量。我们研究了废用性骨质疏松症小鼠模型以及不同骨体积分数的人椎骨的EF分布、SMI和骨小梁几何形状的骨体积分数之间的关系。我们观察到EF中值（在小鼠胫骨疾病后期）和EF模式（在低骨体积分数的椎体样本中）向更棒状的几何形状中度转移，但EF最大值和最小值没有变化。这些结果支持这样一种观点，即钢板到骨棒的转变并不与骨质流失的发生同时发生，当骨质流失发生时，其程度要比SMI所建议的要温和得多。在我们所有的小梁骨样本中存在着各种各样的局部形状，不能直接归类为棒状或板状。
Changes in trabecular micro-architecture are key to our understanding of osteoporosis. Previous work focusing on structure model index (SMI) measurements have concluded that disease progression entails a shift from plates to rods in trabecular bone, but SMI is heavily biased by bone volume fraction. As an alternative to SMI, we proposed the ellipsoid factor (EF) as a continuous measure of local trabecular shape between plate-like and rod-like extremes. We investigated the relationship between EF distributions, SMI and bone volume fraction of the trabecular geometry in a murine model of disuse osteoporosis as well as from human vertebrae of differing bone volume fraction. We observed a moderate shift in EF median (at later disease stages in mouse tibia) and EF mode (in the vertebral samples with low bone volume fraction) towards a more rod-like geometry, but not in EF maximum and minimum. These results support the notion that the plate to rod transition does not coincide with the onset of bone loss and is considerably more moderate, when it does occur, than SMI suggests. A variety of local shapes not straightforward to categorize as rod or plate exist in all our trabecular bone samples.
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DOI：
10.1016/j.msec.2017.03.158
发表时间：
2017-07-01
影响因子：
7.9
作者：
Fuerst, David;Senck, Sascha;Schrempf, Andreas
通讯作者：
Schrempf, Andreas
影响因子：
2.5
作者：
Carrieroa A;Pereirab AF;Wilson AJ;Castagno S;Javaheri B;Pitsillides AA;Marenzana M;Shefelbine SJ
通讯作者：
Shefelbine SJ
影响因子：
4.1
作者：
Goff MG;Slyfield CR;Kummari SR;Tkachenko EV;Fischer SE;Yi YH;Jekir MG;Keaveny TM;Hernandez CJ
通讯作者：
Hernandez CJ
DOI：
10.1098/rspb.2011.0069
发表时间：
2011-10-22
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Doube M;Klosowski MM;Wiktorowicz-Conroy AM;Hutchinson JR;Shefelbine SJ
通讯作者：
Shefelbine SJ
影响因子：
2.4
作者：
GIBSON, LJ
通讯作者：
GIBSON, LJ