Rigor and reproducibility in research with transcranial electrical stimulation: An NIMH-sponsored workshop.
Rigor and reproducibility in research with transcranial electrical stimulation: An NIMH-sponsored workshop.
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DOI：
10.1016/j.brs.2017.12.008
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发表时间：
2018-05
影响因子：
7.7
通讯作者：
Lisanby SH
中科院分区：
文献类型：
--
作者：
Bikson M;Brunoni AR;Charvet LE;Clark VP;Cohen LG;Deng ZD;Dmochowski J;Edwards DJ;Frohlich F;Kappenman ES;Lim KO;Loo C;Mantovani A;McMullen DP;Parra LC;Pearson M;Richardson JD;Rumsey JM;Sehatpour P;Sommers D;Unal G;Wassermann EM;Woods AJ;Lisanby SH
神经精神障碍是残疾的主要来源，需要针对疾病机制的新治疗方法。由于这些疾病被认为是由异常的神经元回路活动引起的，神经调节方法由于其直接操纵回路的潜力而越来越受到关注。采用直流电（经颅直流电刺激，tDCS）或交流电（经颅交流电刺激，tACS）的低强度经颅电刺激（tES）代表了新型、安全、耐受性良好且相对便宜的推定治疗方式。本报告旨在促进这些模式的科学，技术和有效的临床应用，确定研究挑战，并提出解决这些需求的方法，以实现严格的，可重复的研究结果，可以推进临床治疗。美国国家精神卫生研究所（NIMH）于2016年9月召开了一次研讨会，汇集了基础和人类神经科学，电刺激生物物理学和设备以及临床试验方法的专家，以研究tDCS/tACS的生理机制，优化刺激方案的技术和技术策略，以及治疗应用和试验设计的科学状态。在了解机制、方法和技术改进方面的进展（例如，电子学、便于适当给药的计算模型）和改进的临床试验设计准备推进这些技术的严格的、可再现的治疗应用。与会者确定了一些挑战，并提出了应对这些挑战的建议。这些建议与NIMH资助机会公告中的要求一致，除其他需求外，定义剂量学，证明剂量/反应关系，实施严格的盲法试验设计，采用计算建模，并在测试基于刺激的干预措施治疗精神障碍时证明目标参与。
Neuropsychiatric disorders are a leading source of disability and require novel treatments that target mechanisms of disease. As such disorders are thought to result from aberrant neuronal circuit activity, neuromodulation approaches are of increasing interest given their potential for manipulating circuits directly. Low intensity transcranial electrical stimulation (tES) with direct currents (transcranial direct current stimulation, tDCS) or alternating currents (transcranial alternating current stimulation, tACS) represent novel, safe, well-tolerated, and relatively inexpensive putative treatment modalities. This report seeks to promote the science, technology and effective clinical applications of these modalities, identify research challenges, and suggest approaches for addressing these needs in order to achieve rigorous, reproducible findings that can advance clinical treatment. The National Institute of Mental Health (NIMH) convened a workshop in September 2016 that brought together experts in basic and human neuroscience, electrical stimulation biophysics and devices, and clinical trial methods to examine the physiological mechanisms underlying tDCS/tACS, technologies and technical strategies for optimizing stimulation protocols, and the state of the science with respect to therapeutic applications and trial designs. Advances in understanding mechanisms, methodological and technological improvements (e.g., electronics, computational models to facilitate proper dosing), and improved clinical trial designs are poised to advance rigorous, reproducible therapeutic applications of these techniques. A number of challenges were identified and meeting participants made recommendations made to address them. These recommendations align with requirements in NIMH funding opportunity announcements to, among other needs, define dosimetry, demonstrate dose/response relationships, implement rigorous blinded trial designs, employ computational modeling, and demonstrate target engagement when testing stimulation-based interventions for the treatment of mental disorders.
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影响因子：
9.8
作者：
Alagapan S;Schmidt SL;Lefebvre J;Hadar E;Shin HW;Frӧhlich F
通讯作者：
Frӧhlich F
影响因子：
7.7
作者：
Brunye, Tad T.;Cantelon, Julie;Mahoney, Caroline R.
通讯作者：
Mahoney, Caroline R.
DOI：
10.1109/embc.2012.6346036
发表时间：
2012
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
--
作者：
Caparelli-Daquer EM;Zimmermann TJ;Mooshagian E;Parra LC;Rice JK;Datta A;Bikson M;Wassermann EM
通讯作者：
Wassermann EM
影响因子：
2
作者：
Butler, Andrew J.;Shuster, Margaret;Guilkey, Karen
通讯作者：
Guilkey, Karen
影响因子：
5.3
作者：
Ali, Mohsin M.;Sellers, Kristin K.;Frohlich, Flavio
通讯作者：
Frohlich, Flavio