Differential neural activation for updating rule versus stimulus information in working memory.

Differential neural activation for updating rule versus stimulus information in working memory.
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DOI:
10.1016/j.neuron.2008.05.012
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发表时间:
2008-07-10
期刊:
影响因子:
16.2
通讯作者:
Courtney SM
Courtney SM
中科院分区:
医学1区
文献类型:
--
作者:
Montojo CA;Courtney SM

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确定哪些信息在工作记忆(WM)中被积极地保存,以及它是如何被表征和控制的,对于理解这些信息如何指导未来的行为至关重要。工作记忆传统上是从刺激特异性信息(如位置或词语)的维持方面进行研究的。最近,研究人员强调了在这些刺激和待处理的反应之间建立关系的规则的重要性。本研究采用功能磁共振成像的心算任务,以测试是否更新的数字(即刺激)和更新的数学运算(即规则)在WM依赖于同一个神经系统。结果表明,虽然一个共同的网络被激活的两种类型的更新,规则更新优先激活前额叶皮层,而数字更新优先激活顶叶皮层。结果表明,数字和规则都保持在WM,但它们是不同类型的信息,独立控制。
Establishing what information is actively maintained in working memory (WM) and how it is represented and controlled is essential to understanding how such information guides future behavior. WM has traditionally been investigated in terms of the maintenance of stimulus-specific information, such as locations or words. More recently, investigators have emphasized the importance of rules that establish relationships between those stimuli and the pending response. The current study used a mental arithmetic task with fMRI to test whether updating of numbers (i.e. stimuli) and updating of mathematical operations (i.e. rules) in WM relies on the same neural system. Results indicate that while a common network is activated by both types of updating, rule updating preferentially activates prefrontal cortex while number updating preferentially activates parietal cortex. The results suggest that both numbers and rules are maintained in WM, but they are different types of information that are controlled independently.
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