Early manipulation of juvenile hormone has sexually dimorphic effects on mature adult behavior in Drosophila melanogaster.
Early manipulation of juvenile hormone has sexually dimorphic effects on mature adult behavior in Drosophila melanogaster.
复制标题
DOI：
10.1016/j.yhbeh.2013.08.018
复制
发表时间：
2013-09
影响因子：
3.5
通讯作者：
Neckameyer, Wendi S.
中科院分区：
文献类型：
--
作者：
Argue, Kathryn J.;Yun, Amber J.;Neckameyer, Wendi S.
激素对生理系统的发育、成熟和维持至关重要;因此，了解它们在大脑成熟过程中的参与对于阐明成年人成为行为能力的机制非常重要。在性成熟过程中遇到的外源性和内源性因素的变化可能会对成熟的成年人产生长期的影响。在这项研究中，我们研究了促性腺激素，保幼激素（JH），在果蝇成年行为的调制中的作用。在这里，我们利用methoprene（一种合成的JH类似物）和precocene（一种JH合成抑制剂）操纵水平的JH在性不成熟的男性和女性果蝇或没有减少神经元多巴胺（DA）的合成。一旦动物生长到性成熟，就对运动和求偶行为进行分析。结果表明，JH在这些中枢控制的行为，在成熟的动物，这是依赖于年龄的动物测定的调制性二态性的作用，目前DA作为一个候选的神经元因子，差异与JH的相互作用，这取决于动物的性别。数据还表明，JH通过间接机制调节这些行为。由于促性腺激素和DA在哺乳动物中相互作用，影响大脑发育和以后的功能，我们的研究结果表明，这种机制的发展成人行为能力可能是进化保守的。
Hormones are critical for the development, maturation, and maintenance of physiological systems; therefore, understanding their involvement during maturation of the brain is important for the elucidation of mechanisms by which adults become behaviorally competent. Changes in exogenous and endogenous factors encountered during sexual maturation can have long lasting effects in mature adults. In this study, we investigated the role of the gonadotropic hormone, juvenile hormone (JH), in the modulation of adult behaviors in Drosophila. Here we utilized methoprene (a synthetic JH analog) and precocene (a JH synthesis inhibitor) to manipulate levels of JH in sexually immature male and female Drosophila with or without decreased synthesis of neuronal dopamine (DA). Locomotion and courtship behavior were assayed once the animals had grown to sexual maturity. The results demonstrate a sexually dimorphic role for JH in the modulation of these centrally controlled behaviors in mature animals that is dependent on the age of the animals assayed, and present DA as a candidate neuronal factor that differentially interacts with JH depending on the sex of the animal. The data also suggest that JH modulates these behaviors through an indirect mechanism. Since gonadotropic hormones and DA interact in mammals to affect brain development and later function, our results suggest that this mechanism for the development of adult behavioral competence may be evolutionarily conserved.
登录
查看更多内容
DOI：
10.1073/pnas.1116123109
发表时间：
2011-12-27
影响因子：
11.1
作者：
Charles, Jean-Philippe;Iwema, Thomas;Jindra, Marek
通讯作者：
Jindra, Marek
影响因子：
2.2
作者：
Gruntenko, NE;Karpova, EK;Rauschenbach, IY
通讯作者：
Rauschenbach, IY
影响因子：
2.7
作者：
Dubrovsky, EB;Dubrovskaya, VA;Berger, EM
通讯作者：
Berger, EM
影响因子：
3.3
作者：
Neckameyer, W. S.;Matsuo, H.
通讯作者：
Matsuo, H.
影响因子：
--
作者：
HANDLER, AM;POSTLETHWAIT, JH
通讯作者：
POSTLETHWAIT, JH