Functional connectivity of the retrosplenial cortex in rats with ischemic stroke is improved by electroacupuncture
Functional connectivity of the retrosplenial cortex in rats with ischemic stroke is improved by electroacupuncture
复制标题
电针改善缺血性脑卒中大鼠脾后皮质的功能连接
DOI：
10.1177/0964528420921190
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发表时间：
2020-06
影响因子：
2.5
通讯作者：
Tao Jing
中科院分区：
文献类型：
--
作者：
Zhang Qingqing;Li Jianhong;Huang Sheng;Yang Minguang;Liang Shengxiang;Liu Weilin;Chen Lidian;Tao Jing
背景本研究的目的是通过静息态功能磁共振成像（fMRI）研究电针（EA）对缺血性中风引起的认知缺陷大鼠学习和记忆能力的假定有益影响的核心机制。方法建立大脑中动脉闭塞（MCAO）致认知缺陷（MICD）大鼠模型。将大鼠随机分为假手术对照组（SC组，n = 12）、未治疗的MICD模型组（MICD组，n = 12）和在GV20和GV24接受EA治疗的MICD组（MICD + EA组，n = 12）。结果 与MICD组相比，GV20和GV24接受EA的MICD + EA组大鼠在EA后第14天的Morris水迷宫测试中，逃避潜伏期明显缩短，穿越平台位置的次数明显增加，提示EA可显着提高空间学习记忆能力。此外，与MICD组相比，MICD + EA组左压后皮层（RSC）与左海马、左RSC、右RSC、左扣带回、右扣带回、右中脑被盖和右视皮层的功能连接性增强； MICD组显示左侧RSC与左侧海马、右侧海马、左侧RSC、右侧RSC、右侧杏仁体、左侧视觉皮层和右侧视觉皮层的功能连接性降低。结论这些研究结果表明，GV20和GV24电针可能通过增加RSC与海马、扣带回和中脑之间的功能连接来改善MICD大鼠的学习和记忆能力，这对于缺血性中风继发的认知障碍的潜在治疗是令人鼓舞的。
Background The aim of this study was to investigate the central mechanism underlying the putative beneficial effects of electroacupuncture (EA) on learning and memory ability of rats with ischemic stroke-induced cognitive deficits by resting-state functional magnetic resonance imaging (fMRI). Methods A rat model of middle cerebral artery occlusion (MCAO)-induced cognitive deficit (MICD) was established. Rats were randomly assigned into a sham-operated control group (SC group, n = 12), untreated MICD model group (MICD group, n = 12), and MICD group receiving EA treatment at GV20 and GV24 (MICD + EA group, n = 12). Results Compared to the MICD group, rats in the MICD + EA group receiving EA at GV20 and GV24 exhibited significantly shortened escape latency times and crossed the position of the platform a significantly increased number of times during the Morris water maze test on the 14th day after EA, which suggested EA could significantly improve spatial learning and memory ability. Furthermore, compared to the MICD group, functional connectivity of the left retrosplenial cortex (RSC) with the left hippocampus, left RSC, right RSC, left cingulate gyrus, right cingulate gyrus, right tegmentum of midbrain, and right visual cortex was increased in the MICD + EA group; the MICD group showed decreased functional connectivity of the left RSC with the left hippocampus, right hippocampus, left RSC, right RSC, right amygdaloid body, left visual cortex, and right visual cortex. Conclusion These findings suggest that EA at GV20 and GV24 might improve the learning and memory ability of MICD rats by increasing the functional connectivity between the RSC and hippocampus, cingulate gyrus and midbrain, which is encouraging for the potential treatment for cognitive impairment secondary to ischemia stroke.
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影响因子：
5.7
作者：
Zanto TP;Pa J;Gazzaley A
通讯作者：
Gazzaley A
影响因子：
4.8
作者：
Nie, Binbin;Chen, Kewei;Zhao, Shujun;Liu, Junhua;Gu, Xiaochun;Yao, Qunli;Hui, Jiaojie;Zhang, Zhijun;Teng, Gaojun;Zhao, Chunjie;Shan, Baoci
通讯作者：
Shan, Baoci
影响因子：
3.4
作者：
Feng, Xiaodong;Yang, Shanli;Chen, Lidian
通讯作者：
Chen, Lidian
影响因子：
3.7
作者：
Vedder, Lindsey C.;Miller, Adam M. P.;Smith, David M.
通讯作者：
Smith, David M.
影响因子：
2.7
作者：
Whishaw, IQ;Maaswinkel, H;Kolb, B
通讯作者：
Kolb, B