Reliability measures of functional magnetic resonance imaging in a longitudinal evaluation of mild cognitive impairment.
Reliability measures of functional magnetic resonance imaging in a longitudinal evaluation of mild cognitive impairment.
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DOI：
10.1016/j.neuroimage.2013.08.063
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发表时间：
2014-01-01
期刊：
影响因子：
5.7
通讯作者：
Gazzaley A
中科院分区：
文献类型：
--
作者：
Zanto TP;Pa J;Gazzaley A
随着老龄化人口的增长，仔细描述遗忘型轻度认知障碍（aMCI）（阿尔茨海默病（AD）的临床前阶段）变得越来越重要。功能性磁共振成像（fMRI）是监测与AD神经病理学相关的选择性脆弱大脑区域疾病进展的宝贵工具。然而，功能磁共振成像数据的可靠性与aMCI的老年人的纵向研究在很大程度上是未经探索的。为了解决这个问题，aMCI参与者在三个月的时间内完成了两项视觉工作任务，一项延迟识别任务和一项单背任务。采用组内相关（ICC）分析方法对功能磁共振血氧水平依赖（BOLD）活动的重测信度进行了评估。结果表明，与任务未使用的区域相比，任务期间参与的大脑区域在整个会话中显示出更大的可靠性。在任务参与过程中，在整个大脑中观察到不同的可靠性分数，额叶，内侧颞叶和皮质下结构表现出中等至中等的可靠性（ICC = 0.3 - 0.6），而颞叶，顶叶和枕叶区域表现出中等至良好的可靠性（ICC = 0.4 - 0.7）。此外，在ICC计算中使用三个fMRI会话时，相对于两个fMRI会话，跨大脑区域的可靠性更稳定。总之，fMRI BOLD信号在该人群的扫描过程中是可靠的，因此是跟踪aMCI观察性和干预性研究中纵向变化的有用工具。
As the aging population grows, it has become increasingly important to carefully characterize amnestic mild cognitive impairment (aMCI), a preclinical stage of Alzheimer’s disease (AD). Functional magnetic resonance imaging (fMRI) is a valuable tool for monitoring disease progression in selectively vulnerable brain regions associated with AD neuropathology. However, the reliability of fMRI data in longitudinal studies of older adults with aMCI is largely unexplored. To address this, aMCI participants completed two visual working tasks, a delayed-recognition task and a one-back task, on three separate scanning sessions over a three-month period. Test-retest reliability of the fMRI blood oxygen level dependent (BOLD) activity was assessed using an intraclass correlation (ICC) analysis approach. Results indicated that brain regions engaged during the task displayed greater reliability across sessions compared to regions that were not utilized by the task. During task-engagement, differential reliability scores were observed across the brain such that the frontal lobe, medial temporal lobe, and subcortical structures exhibited fair to moderate reliability (ICC = 0.3 – 0.6), while temporal, parietal, and occipital regions exhibited moderate to good reliability (ICC = 0.4 – 0.7). Additionally, reliability across brain regions was more stable when three fMRI sessions were used in the ICC calculation relative to two fMRI sessions. In conclusion, the fMRI BOLD signal is reliable across scanning sessions in this population and thus a useful tool for tracking longitudinal change in observational and interventional studies in aMCI.
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