Microfluidic pneumatic logic circuits and digital pneumatic microprocessors for integrated microfluidic systems.
Microfluidic pneumatic logic circuits and digital pneumatic microprocessors for integrated microfluidic systems.
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DOI：
10.1039/b904354c
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发表时间：
2009-11-07
期刊：
影响因子：
6.1
通讯作者：
Burns MA
中科院分区：
文献类型：
--
作者：
Rhee M;Burns MA
我们开发了气动逻辑电路和微处理器，内置微流体通道和阀门，聚二甲基硅氧烷（PDMS）。气动逻辑电路使用二进制气动信号（大气和真空）执行各种组合和顺序逻辑计算，并基于布尔运算产生可重复的输出。一个复杂的微处理器是由各种逻辑电路的组合构成的，并在一条输入线上接收经串行编码的串行命令。然后，该设备通过空间并行化对时间命令序列进行解码，在并行化的命令位之间计算必要的逻辑运算，存储用于信号传输和维护的命令信息，并最终执行针对目标设备的命令。因此，这样的气动微处理器将作为一个通用的芯片上的控制平台来执行复杂的并行操作的大规模集成微流体设备。为了展示工作原理，我们已经构建了2位，3位，4位和8位微处理器来控制各种目标设备，用于四色染料混合和多路通道流体控制等应用。通过显著减少对外部控制器的需求，数字气动微处理器可用作通用片上平台，以高通量方式自主操纵微流体。
We have developed pneumatic logic circuits and microprocessors built with microfluidic channels and valves in polydimethylsiloxane (PDMS). The pneumatic logic circuits perform various combinational and sequential logic calculations with binary pneumatic signals (atmosphere and vacuum), producing cascadable outputs based on Boolean operations. A complex microprocessor is constructed from combinations of various logic circuits and receives pneumatically encoded serial commands at a single input line. The device then decodes the temporal command sequence by spatial parallelization, computes necessary logic calculations between parallelized command bits, stores command information for signal transportation and maintenance, and finally executes the command for the target devices. Thus, such pneumatic microprocessors will function as a universal on-chip control platform to perform complex parallel operations for large-scale integrated microfluidic devices. To demonstrate the working principles, we have built 2-bit, 3-bit, 4-bit, and 8-bit microprecessors to control various target devices for applications such as four color dye mixing, and multiplexed channel fluidic control. By significantly reducing the need for external controllers, the digital pneumatic microprocessor can be used as a universal on-chip platform to autonomously manipulate microfluids in a high throughput manner.
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