High-Density Stretchable Electrode Grids for Chronic Neural Recording.
High-Density Stretchable Electrode Grids for Chronic Neural Recording.
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DOI：
10.1002/adma.201706520
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Vörös J
中科院分区：
文献类型：
--
作者：
Tybrandt K;Khodagholy D;Dielacher B;Stauffer F;Renz AF;Buzsáki G;Vörös J
与神经组织的电子接口是推进神经疾病诊断和治疗以及提供有关神经信号的详细信息的关键。在电子学和神经组织之间建立长期稳定的接口的一个挑战是系统之间巨大的机械不匹配。到目前为止，材料和制造工艺限制了能够结合高性能、长期稳定和高电极密度的软电极网格的发展，这些方面都是神经接口所必需的。在这里，通过开发一种基于惰性、高性能复合材料的柔软、高密度、可伸展的电极网来应对这一挑战，该复合材料包含嵌入在硅胶基质中的镀金二氧化钛纳米线。研制的网格能够分辨自由活动大鼠大脑皮质表面的高时空神经信号，在植入3个月期间具有稳定的神经记录质量和保持电极信号的一致性。由于其灵活和可伸展的性质，有可能将放置所需的开颅大小降至最小，从而进一步降低侵袭性。本文提出的材料和装置技术具有广泛的新兴生物医学应用的潜力。
Electrical interfacing with neural tissue is key to advancing diagnosis and therapies for neurological disorders, as well as providing detailed information about neural signals. A challenge for creating long-term stable interfaces between electronics and neural tissue is the huge mechanical mismatch between the systems. So far, materials and fabrication processes have restricted the development of soft electrode grids able to combine high performance, long-term stability, and high electrode density, aspects all essential for neural interfacing. Here, this challenge is addressed by developing a soft, high-density, stretchable electrode grid based on an inert, high-performance composite material comprising gold-coated titanium dioxide nanowires embedded in a silicone matrix. The developed grid can resolve high spatiotemporal neural signals from the surface of the cortex in freely moving rats with stable neural recording quality and preserved electrode signal coherence during 3 months of implantation. Due to its flexible and stretchable nature, it is possible to minimize the size of the craniotomy required for placement, further reducing the level of invasiveness. The material and device technology presented herein have potential for a wide range of emerging biomedical applications.
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DOI：
10.1126/science.aan6203
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Khodagholy D;Gelinas JN;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
56.9
作者：
Minev, Ivan R.;Musienko, Pavel;Lacour, Stephanie P.
通讯作者：
Lacour, Stephanie P.
影响因子：
29
作者：
Krook-Magnuson E;Gelinas JN;Soltesz I;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
3.9
作者：
Marzun, Galina;Streich, Carmen;Wagener, Philipp
通讯作者：
Wagener, Philipp
影响因子：
38.3
作者：
Park, Minwoo;Im, Jungkyun;Kim, Kinam
通讯作者：
Kim, Kinam