HIV and SARS-CoV-2 infection in postpartum Kenyan women and their infants.
HIV and SARS-CoV-2 infection in postpartum Kenyan women and their infants.
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DOI：
10.1371/journal.pone.0278675
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
Gantt, Soren
中科院分区：
文献类型：
--
作者：
Begnel, Emily R.;Chohan, Bhavna H.;Ojee, Ednah;Adhiambo, Judith;Owiti, Prestone;Ogweno, Vincent;Holland, LaRinda A.;Fish, Carolyn S.;Richardson, Barbra A.;Khan, Adam K.;Maqsood, Rabia;Lim, Efrem S.;Sadarangani, Manish;Lehman, Dara A.;Slyker, Jennifer;Kinuthia, John;Wamalwa, Dalton;Gantt, Soren
艾滋病毒可能会增加SARS-CoV-2感染风险和COVID-19的严重程度，但有关其对产后妇女及其婴儿影响的数据有限。因此，我们对肯尼亚内罗毕母婴对的SARS-CoV-2感染进行了表征。我们对62名未感染艾滋病毒的妇女和64名健康的艾滋病毒感染妇女以及她们的未感染艾滋病毒的暴露婴儿（N = 61）和未感染艾滋病毒的暴露婴儿（N = 64）进行了一项嵌套研究，这些婴儿参加了一个前瞻性队列。对2020年5月1日至2022年2月1日期间采集的血浆进行SARS-CoV-2血清学检测，以确定感染的发病率、危险因素和症状。还对血清反应阳性参与者的粪便样本进行了SARS-CoV-2 RNA PCR和测序。SARS-CoV-2血清阳性率在126名母亲中为66%，在125名婴儿中为44%。SARS-CoV-2感染与母亲HIV（风险比[HR] = 0.810，95% CI：0.517-1.27）或婴儿HIV暴露（HR = 1.47，95% CI：0.859-2.53）之间无显著相关性。母亲SARS-CoV-2与婴儿感染风险增加2倍相关（HR = 2.31，95%CI：1.08-4.94）。很少有参与者（13%的母亲，33%的婴儿）有症状;没有参与者经历过严重的COVID-19或死亡。大约一半的母亲和婴儿发生血清逆转。从粪便中获得的SARS-CoV-2序列与同期循环的变体有关。这些数据表明，产后肯尼亚妇女及其婴儿感染SARS-CoV-2的风险很高，抗体反应平均在8-10个月内减弱。然而，大多数病例无症状，感染艾滋病毒的健康女性感染或严重COVID-19的风险并未大幅增加。
HIV may increase SARS-CoV-2 infection risk and COVID-19 severity generally, but data are limited about its impact on postpartum women and their infants. As such, we characterized SARS-CoV-2 infection among mother-infant pairs in Nairobi, Kenya. We conducted a nested study of 62 HIV-uninfected and 64 healthy women living with HIV, as well as their HIV-exposed uninfected (N = 61) and HIV-unexposed (N = 64) infants, participating in a prospective cohort. SARS-CoV-2 serology was performed on plasma collected between May 1, 2020-February 1, 2022 to determine the incidence, risk factors, and symptoms of infection. SARS-CoV-2 RNA PCR and sequencing was also performed on available stool samples from seropositive participants. SARS-CoV-2 seropositivity was found in 66% of the 126 mothers and in 44% of the 125 infants. There was no significant association between SARS-CoV-2 infection and maternal HIV (Hazard Ratio [HR] = 0.810, 95% CI: 0.517–1.27) or infant HIV exposure (HR = 1.47, 95% CI: 0.859–2.53). Maternal SARS-CoV-2 was associated with a two-fold increased risk of infant infection (HR = 2.31, 95% CI: 1.08–4.94). Few participants (13% mothers, 33% infants) had symptoms; no participant experienced severe COVID-19 or death. Seroreversion occurred in about half of mothers and infants. SARS-CoV-2 sequences obtained from stool were related to contemporaneously circulating variants. These data indicate that postpartum Kenyan women and their infants were at high risk for SARS-CoV-2 infection and that antibody responses waned over an average of 8–10 months. However, most cases were asymptomatic and healthy women living with HIV did not have a substantially increased risk of infection or severe COVID-19.
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DOI：
10.1093/infdis/jiaa691
发表时间：
2021-02-13
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Goldstein E;Lipsitch M;Cevik M
通讯作者：
Cevik M
DOI：
10.1016/s0140-6736(21)00441-4
发表时间：
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影响因子：
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作者：
African COVID-19 Critical Care Outcomes Study (ACCCOS) Investigators
通讯作者：
African COVID-19 Critical Care Outcomes Study (ACCCOS) Investigators
影响因子：
10.7
作者：
Hoang DT;Chernomor O;von Haeseler A;Minh BQ;Vinh LS
通讯作者：
Vinh LS
DOI：
10.3390/ijerph18073554
发表时间：
2021-03-30
影响因子：
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作者：
Lee KW;Yap SF;Ngeow YF;Lye MS
通讯作者：
Lye MS
影响因子：
1.6
作者：
Dong Y;Li Z;Ding S;Liu S;Tang Z;Jia L;Liu J;Liu Y
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Liu Y