Niche inheritance: a cooperative pathway to enhance cancer cell fitness through ecosystem engineering.

Niche inheritance: a cooperative pathway to enhance cancer cell fitness through ecosystem engineering.
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DOI:
10.1002/jcb.24813
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发表时间:
2014-09
影响因子:
4
通讯作者:
Pienta, Kenneth J.
Pienta, Kenneth J.
中科院分区:
生物学2区
文献类型:
--
作者:
Yang, Kimberline R.;Mooney, Steven M.;Zarif, Jelani C.;Coffey, Donald S.;Taichman, Russell S.;Pienta, Kenneth J.

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癌细胞可以被描述为能够在新环境中建立自己的入侵物种。生态位构建的概念可以用来描述癌细胞改造其环境的过程,从而设计一个促进物种遗传适应性的生态系统。然后,可以利用生态扩散理论来描述和模拟成功的流散所涉及的步骤和障碍,因为癌细胞离开原始宿主器官并迁移到新的宿主器官,以成功地建立新的转移社区。这些生态概念可以进一步用于定义致命癌症的新诊断和治疗领域。115:1478-1485,2014.© 2014 Wiley Periodicals,Inc.
Cancer cells can be described as an invasive species that is able to establish itself in a new environment. The concept of niche construction can be utilized to describe the process by which cancer cells terraform their environment, thereby engineering an ecosystem that promotes the genetic fitness of the species. Ecological dispersion theory can then be utilized to describe and model the steps and barriers involved in a successful diaspora as the cancer cells leave the original host organ and migrate to new host organs to successfully establish a new metastatic community. These ecological concepts can be further utilized to define new diagnostic and therapeutic areas for lethal cancers. 115: 1478–1485, 2014. © 2014 Wiley Periodicals, Inc.
DOI: 10.1038/newbio242148a0
发表时间: 1973-01-01
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