Quantitative methods for reconstructing tissue biomechanical properties in optical coherence elastography: a comparison study.
Quantitative methods for reconstructing tissue biomechanical properties in optical coherence elastography: a comparison study.
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DOI：
10.1088/0031-9155/60/9/3531
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发表时间：
2015-05-07
影响因子：
3.5
通讯作者：
Larin KV
中科院分区：
文献类型：
--
作者：
Han Z;Li J;Singh M;Wu C;Liu CH;Wang S;Idugboe R;Raghunathan R;Sudheendran N;Aglyamov SR;Twa MD;Larin KV
我们提出了一个系统的准确性分析五种不同的方法提取生物力学性质的软样品使用光学相干弹性成像（OCE）。OCE是一种新兴的非侵入性技术，它可以以微米级的空间分辨率评估组织的生物力学特性。然而，为了准确地从OCE测量中提取生物力学特性，需要应用适当的力学模型。在这项研究中，我们利用具有控制弹性特性的组织模拟模型，并研究了基于空气脉冲诱导弹性波的OCE测量来重建弹性（杨氏模量）的四种可用方法的可行性。基于剪切波方程（SWE）、表面波方程（SuWE）、Rayleigh-Lamb频率方程（RLFE）和有限元法（FEM），将弹性值与单轴力学试验进行了比较。结果表明，相对于其他简化模型，RLFE和FEM在定量评估弹性方面具有更强的鲁棒性。本研究为利用OCE数据重建组织的生物力学特性提供了基础和参考，对无创弹性成像方法的进一步发展具有重要意义。
We present a systematic analysis of the accuracy of five different methods for extracting the biomechanical properties of soft samples using optical coherence elastography (OCE). OCE is an emerging noninvasive technique, which allows assessing biomechanical properties of tissues with a micrometer spatial resolution. However, in order to accurately extract biomechanical properties from OCE measurements, application of proper mechanical model is required. In this study, we utilize tissue-mimicking phantoms with controlled elastic properties and investigate the feasibilities of four available methods for reconstructing elasticity (Young’s modulus) based on OCE measurements of an air-pulse induced elastic wave. The approaches are based on the shear wave equation (SWE), the surface wave equation (SuWE), Rayleigh-Lamb frequency equation (RLFE), and finite element method (FEM), Elasticity values were compared with uniaxial mechanical testing. The results show that the RLFE and the FEM are more robust in quantitatively assessing elasticity than the other simplified models. This study provides a foundation and reference for reconstructing the biomechanical properties of tissues from OCE data, which is important for the further development of noninvasive elastography methods.
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DOI：
10.1098/rsif.2014.0920
发表时间：
2014-12-06
期刊：
Journal of the Royal Society, Interface
影响因子：
--
作者：
Kling S;Akca IB;Chang EW;Scarcelli G;Bekesi N;Yun SH;Marcos S
通讯作者：
Marcos S
DOI：
10.1186/bcr2787
发表时间：
2010
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Evans A;Whelehan P;Thomson K;McLean D;Brauer K;Purdie C;Jordan L;Baker L;Thompson A
通讯作者：
Thompson A
影响因子：
--
作者：
Ko, HJ;Tan, W;Boppart, SA
通讯作者：
Boppart, SA
影响因子：
2
作者：
Kotecha A;Russell RA;Sinapis A;Pourjavan S;Sinapis D;Garway-Heath DF
通讯作者：
Garway-Heath DF
影响因子：
3.5
作者：
Kennedy, Kelsey M.;Ford, Chris;Sampson, David D.
通讯作者：
Sampson, David D.