Medial temporal lobe structure, mnemonic and perceptual discrimination in healthy older adults and those at risk for mild cognitive impairment
Medial temporal lobe structure, mnemonic and perceptual discrimination in healthy older adults and those at risk for mild cognitive impairment
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健康老年人和有轻度认知障碍风险的人的内侧颞叶结构、记忆和知觉辨别
DOI：
10.1101/2022.05.13.491810
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Gellersen H
中科院分区：
文献类型：
--
作者：
Gellersen H
对内侧颞叶(MTL)完整性敏感的认知测试，如对知觉相似刺激的助记辨别，可能是老年人群认知能力下降的有用早期标志。对具有重叠特征的刺激的知觉辨别也依赖于MTL，但在这一背景下仍然相对未被探索。我们以两种测试形式(强迫选择，是/否)评估了111名社区老年人在神经心理筛查的基础上对不同认知障碍风险状态的物体和场景的知觉辨别能力。我们还研究了性能与MTL亚区体积和厚度之间的关系。高危人群的内嗅器厚度减少，知觉和记忆辨别能力受损。知觉辨别损害部分解释了组内助记辨别能力的差异，并与内嗅觉厚度相关。在高危成年人中，执行功能障碍是/否缺陷的原因，这表明了测试形式对于解释记忆衰退的重要性。这些结果表明，知觉辨别任务可能是检测非临床人群中与MTL完整性降低相关的早期认知损害的有用工具。
Cognitive tests sensitive to the integrity of the medial temporal lobe (MTL), such as mnemonic discrimination of perceptually similar stimuli, may be useful early markers of risk for cognitive decline in older populations. Perceptual discrimination of stimuli with overlapping features also relies on MTL but remains relatively unexplored in this context. We assessed mnemonic discrimination in two test formats (Forced Choice, Yes/No) and perceptual discrimination of objects and scenes in 111 community-dwelling older adults at different risk status for cognitive impairment based on neuropsychological screening. We also investigated associations between performance and MTL sub-region volume and thickness. The at-risk group exhibited reduced entorhinal thickness and impaired perceptual and mnemonic discrimination. Perceptual discrimination impairment partially explained group differences in mnemonic discrimination and correlated with entorhinal thickness. Executive dysfunction accounted for Yes/No deficits in at-risk adults, demonstrating the importance of test format for the interpretation of memory decline. These results suggest that perceptual discrimination tasks may be useful tools for detecting incipient cognitive impairment related to reduced MTL integrity in nonclinical populations.
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内侧颞叶皮层的内容调整：感知、检索的体素
影响因子：
3.4
作者：
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通讯作者：
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影响因子：
3.8
作者：
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通讯作者：
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影响因子：
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作者：
Barense, Morgan D.;Henson, Richard N. A.;Lee, Andy C. H.;Graham, Kim S.
通讯作者：
Graham, Kim S.
DOI：
10.1080/13825585.2016.1158235
发表时间：
2016-11
期刊：
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
影响因子：
--
作者：
D'Angelo MC;Smith VM;Kacollja A;Zhang F;Binns MA;Barense MD;Ryan JD
通讯作者：
Ryan JD
影响因子：
3.6
作者：
Besson, Gabriel;Simon, Jessica;Bastin, Christine
通讯作者：
Bastin, Christine