Content Tuning in the Medial Temporal Lobe Cortex: Voxels that Perceive, Retrieve
Content Tuning in the Medial Temporal Lobe Cortex: Voxels that Perceive, Retrieve
复制标题
内侧颞叶皮层的内容调整：感知、检索的体素
作者：
Heidrun Schultz;Roni Tibon;Karen F. LaRocque;S. Gagnon;A. Wagner;B. Staresina
我们如何仅根据稀疏的线索回忆起过去的生动细节？研究表明，对过去经验的现象学恢复伴随着对原始知觉的神经恢复。这一过程主要依赖于内侧颞叶（MTL）。在MTL中，周围皮层（PRC）和海马体旁皮层（PHC）被认为分别支持对象和场景的编码和回忆，海马体（HC）作为内容独立的中枢。如果回忆的保真度确实源于感知活动的神经恢复，那么成功的回忆应该优先利用那些在感知过程中对内容敏感的MTL皮层内的神经群，这些神经群在感知过程中被调谐到相同的内容。为了验证这一假设，我们让18名参与者在编码和回忆与单词配对的物体和场景时接受功能性核磁共振成像（fMRI）检查。关键的是，回忆只受到单词的提示。虽然HC区分成功和不成功的物体和场景的回忆，PRC和PHC分别在成功和不成功的物体和场景的回忆中优先参与。重要的是，在PRC和PHC中，这种内容敏感的回忆是通过感知过程中的内容调整来预测的：在PRC体素中，我们观察到感知过程中的对象调整与成功的对象回忆之间存在正相关关系，而在PHC体素中，我们观察到感知过程中的场景调整与成功的场景回忆之间存在正相关关系。因此，我们的研究结果强调了MTL皮层区域在情景记忆中的基于内容的作用，并揭示了感知过程中特定内容调谐与成功回忆之间的直接映射。
Abstract How do we recall vivid details from our past based only on sparse cues? Research suggests that the phenomenological reinstatement of past experiences is accompanied by neural reinstatement of the original percept. This process critically depends on the medial temporal lobe (MTL). Within the MTL, perirhinal cortex (PRC) and parahippocampal cortex (PHC) are thought to support encoding and recall of objects and scenes, respectively, with the hippocampus (HC) serving as a content-independent hub. If the fidelity of recall indeed arises from neural reinstatement of perceptual activity, then successful recall should preferentially draw upon those neural populations within content-sensitive MTL cortex that are tuned to the same content during perception. We tested this hypothesis by having eighteen human participants undergo functional MRI (fMRI) while they encoded and recalled objects and scenes paired with words. Critically, recall was cued with the words only. While HC distinguished successful from unsuccessful recall of both objects and scenes, PRC and PHC were preferentially engaged during successful versus unsuccessful object and scene recall, respectively. Importantly, within PRC and PHC, this content-sensitive recall was predicted by content tuning during perception: Across PRC voxels, we observed a positive relationship between object tuning during perception and successful object recall, while across PHC voxels, we observed a positive relationship between scene tuning during perception and successful scene recall. Our results thus highlight content-based roles of MTL cortical regions for episodic memory and reveal a direct mapping between content-specific tuning during perception and successful recall.
登录
查看更多内容
DOI：
10.1073/pnas.97.20.11125
发表时间：
2000-09-26
影响因子：
11.1
作者：
Wheeler, ME;Petersen, SE;Buckner, RL
通讯作者：
Buckner, RL
DOI：
--
发表时间：
--
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Talia Konkle;Timothy F. Brady;G. Alvarez;A. Oliva
通讯作者：
Talia Konkle;Timothy F. Brady;G. Alvarez;A. Oliva
影响因子：
22.4
作者：
Danker, Jared F.;Anderson, John R.
通讯作者：
Anderson, John R.
知识通过熟悉而不是回忆来支持记忆检索。
影响因子：
2.6
作者：
Wang,Wei-Chun;Brashier,NadiaM;Wing,ErikA;Marsh,ElizabethJ;Cabeza,Roberto
通讯作者：
Cabeza,Roberto
影响因子：
13.9
作者：
Squire LR;Wixted JT
通讯作者：
Wixted JT