Influenza Viral Infections Enhance Sleep in Mice
Influenza Viral Infections Enhance Sleep in Mice
复制标题
流感病毒感染可增强小鼠的睡眠
DOI：
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
J. Krueger
中科院分区：
文献类型：
--
作者：
Jidong Fang;C. Sanborn;K. B. Renegar;J. A. Majde;J. Krueger
摘要嗜睡是病毒感染过程中常见的感觉。然而，关于病毒感染对睡眠的影响知之甚少。本研究的目的是测试流感病毒感染是否会改变小鼠的睡眠。经过2-3天的基线睡眠记录后，Swiss-Webster小鼠鼻内感染致命（H1N1）或非致命（H3 N2）流感病毒株。再次记录额外3天的睡眠。接种H1N1病毒后，非快速眼动睡眠（NREMS）显著增加，潜伏期约为16 h，而快速眼动睡眠（REMS）则在较长潜伏期后受到显著抑制。这两种变化持续到记录结束，并且发生在幼龄（35日龄）和成年（90- 100日龄）动物中。对照组动物在用尿囊液假感染后睡眠没有变化。H1N1病毒还引起体温和运动活动的急剧下降，潜伏期约为病毒接种后4-5小时。H3 N2病毒在睡眠中引起了非常相似的变化，尽管其影响程度比H1N1病毒小得多，尽管使用的H3 N2病毒剂量要高得多（10倍）。目前的研究表明，流感病毒感染诱导NREMS的深刻和持久的增加和抑制REMS。这些病毒引起的睡眠变化可能代表了宿主的防御反应。[P.S.E.B.M. 1995年，第210页]
Abstract Sleepiness is a common perception during viral infection. Nevertheless, very little is known about the effects of viral infection on sleep. The aim of the present study was to test whether sleep was altered by influenza viral infection in mice. After 2-3 days of baseline sleep recordings, Swiss-Webster mice were infected intranasally with a lethal (H1N1) or a nonlethal (H3N2) strain of influenza virus. Sleep was recorded again for an additional 3 days. Non–rapid eye movement sleep (NREMS) was dramatically increased after inoculation of the H1N1 virus with a latency about 16 hr. Rapid eye movement sleep (REMS) was significantly suppressed after a longer latency. Both changes lasted until the end of the recording and occurred in both young (35-day-old) and adult (90- to 100-day-old) animals. Control animals did not show changes in sleep after sham infection with allantoic fluid. The H1N1 virus also caused dramatic decreases in body temperature and locomotor activities with a latency about 4-5 hr after viral inoculation. The H3N2 virus induced very similar changes in sleep, although the effects were much smaller in magnitude than those induced by the H1N1 virus, even though a much higher dose (10-fold) of the H3N2 virus was used. The present study shows that influenza viral infection induces profound and long-lasting increase of NREMS and suppression of REMS. These viral-induced changes in sleep likely represent a host-defense response. [P.S.E.B.M. 1995, Vol 210]
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在白细胞介素 1 增强睡眠期间，与睡眠状态相关的大脑温度变化持续存在。
DOI：
10.1152/ajpregu.1986.250.1.r96
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Walter,J;Davenne,D;Shoham,S;Dinarello,CA;Krueger,JM
通讯作者：
Krueger,JM
α-MSH 对睡眠、行为和脑温度的影响：与 IL 1 的相互作用。
DOI：
10.1152/ajpregu.1988.255.6.r914
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
--
作者：
Opp,MR;ObalJr,F;Krueger,JM
通讯作者：
Krueger,JM
影响因子：
4.4
作者：
K. B. Renegar;P. Small
通讯作者：
K. B. Renegar;P. Small
影响因子：
--
作者：
KRUEGER, JM;WALTER, J;CHEDID, L
通讯作者：
CHEDID, L
流感感染的结果：初始感染部位和异型免疫的影响。
影响因子：
3.1
作者：
Yetter,RA;Lehrer,S;Ramphal,R;SmallJr,PA
通讯作者：
SmallJr,PA