Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice.
Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice.
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DOI：
10.1038/s41598-017-09340-9
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发表时间：
2017-08-17
影响因子：
4.6
通讯作者：
Chen HL
中科院分区：
文献类型：
--
作者：
Fu YF;Jiang LH;Zhao WD;Xi-Nan M;Huang SQ;Yang J;Hu TJ;Chen HL
Oxidative stress plays an important role in the pathogenesis of virus infection and antioxidants are becoming promising candidates as therapeutic agents. This study is designed to investigate the effect of total flavonoids of Spatholobus suberectus Dunn (TFSD) on oxidative stress in mice induced by porcine circovirus type 2 (PCV2) infection. The PCV2 infection leads to significant decrease in thymus and spleen indices, elevation of xanthine oxidase (XOD) and myeloperoxidase (MPO) activities, reduction in GSH level and GSH to GSSG ratio and decline of superoxide dismutase (SOD) activity, indicating the formation of immunosuppression and oxidative stress. TFSD treatment recovered the alteration of viscera index, antioxidant content and activities of oxidative-associated enzymes to a level similar to control. Our findings suggested that PCV2 induced immunosuppression and oxidative stress in mice and TFSD might be able to protect animals from virus infection via regulation of immune function and inhibition of oxidative stress.
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影响因子：
1.8
作者：
Chianini F;Majó N;Segalés J;Domínguez J;Domingo M
通讯作者：
Domingo M
影响因子：
--
作者：
Reshi ML;Su YC;Hong JR
通讯作者：
Hong JR
影响因子：
--
作者：
Chen HL;Yang J;Fu YF;Meng XN;Zhao WD;Hu TJ
通讯作者：
Hu TJ
影响因子：
5.4
作者：
Li, RW;Lin, GD;Leach, DN
通讯作者：
Leach, DN
DOI：
10.1146/annurev-animal-031412-103720
发表时间：
2013-01-01
期刊：
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 1
影响因子：
--
作者：
Meng, Xiang-Jin
通讯作者：
Meng, Xiang-Jin