SARS-CoV-2 tests, confirmed infections and COVID-19-related hospital admissions in children and young people: birth cohort study.
SARS-CoV-2 tests, confirmed infections and COVID-19-related hospital admissions in children and young people: birth cohort study.
复制标题
DOI：
10.1136/bmjpo-2022-001545
复制
发表时间：
2022-08
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
目前还没有针对整个儿科年龄范围内的 SARS-CoV-2 检测、PCR 确诊感染和与 COVID-19 相关的住院情况进行基于人群的研究。我们研究了 23 岁以下儿童和青少年 (CYP) 中 SARS-CoV-2 的流行病学。我们使用了自 1997 年以来在苏格兰出生的所有儿童的出生队列，该队列是通过生命统计数据、医院记录和 SARS-CoV-2 监测数据之间的联系构建的。我们计算了 2020 年 8 月至 12 月期间每 1000 CYP 年的检测和 PCR 确诊感染风险，以及 2020 年 2 月至 12 月期间每 100 000 CYP 年的 COVID-19 相关入院风险。我们使用 Poisson 和 Cox 比例风险回归模型来确定风险因素。在该队列的 1 226 855 CYP 中，有 378 402 例检测（比率为 770.8/1000 CYP 年（95% CI 768.4 至 773.3）），PCR 确诊感染 19 005 例（179.4/1000 CYP 年（176.9 至 182.0）） 346 名入院人数（29.4/100 000 CYP 年（26.3 至 32.8））。婴儿与 COVID-19 相关的入院率最高。慢性病的存在，特别是多种类型的疾病，与所有年龄段的 COVID-19 相关入院密切相关。总体而言，49% 的入院 CYP 患者至少患有一种慢性病。婴儿和患有慢性病的 CYP 感染 COVID-19 的风险最高。一半入院的 CYP 患有慢性病。迫切需要研究检查 COVID-19 疫苗对患有慢性病的儿童的有效性，以及怀孕期间母亲接种疫苗是否可以预防婴儿感染 COVID-19。
There have been no population-based studies of SARS-CoV-2 testing, PCR-confirmed infections and COVID-19-related hospital admissions across the full paediatric age range. We examine the epidemiology of SARS-CoV-2 in children and young people (CYP) aged <23 years. We used a birth cohort of all children born in Scotland since 1997, constructed via linkage between vital statistics, hospital records and SARS-CoV-2 surveillance data. We calculated risks of tests and PCR-confirmed infections per 1000 CYP-years between August and December 2020, and COVID-19-related hospital admissions per 100 000 CYP-years between February and December 2020. We used Poisson and Cox proportional hazards regression models to determine risk factors. Among the 1 226 855 CYP in the cohort, there were 378 402 tests (a rate of 770.8/1000 CYP-years (95% CI 768.4 to 773.3)), 19 005 PCR-confirmed infections (179.4/1000 CYP-years (176.9 to 182.0)) and 346 admissions (29.4/100 000 CYP-years (26.3 to 32.8)). Infants had the highest COVID-19-related admission rates. The presence of chronic conditions, particularly multiple types of conditions, was strongly associated with COVID-19-related admissions across all ages. Overall, 49% of admitted CYP had at least one chronic condition recorded. Infants and CYP with chronic conditions are at highest risk of admission with COVID-19. Half of admitted CYP had chronic conditions. Studies examining COVID-19 vaccine effectiveness among children with chronic conditions and whether maternal vaccine during pregnancy prevents COVID-19 admissions in infants are urgently needed.
登录
查看更多内容
影响因子：
2.9
作者：
Favarato G;Clemens T;Cunningham S;Dibben C;Macfarlane A;Milojevic A;Taylor J;Wijlaars LPMM;Wood R;Hardelid P
通讯作者：
Hardelid P
影响因子：
11.8
作者：
Dabrera, Gavin;Amirthalingam, Gayatri;Ramsay, Mary
通讯作者：
Ramsay, Mary
影响因子：
36.4
作者：
Goetzinger, Florian;Santiago-Garcia, Begona;Tebruegge, Marc
通讯作者：
Tebruegge, Marc
影响因子：
24.3
作者：
Hardelid, Pia;Verfuerden, Maximiliane;Gilbert, Ruth
通讯作者：
Gilbert, Ruth
DOI：
10.1016/j.lanepe.2021.100075
发表时间：
2021-04
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Flood J;Shingleton J;Bennett E;Walker B;Amin-Chowdhury Z;Oligbu G;Avis J;Lynn RM;Davis P;Bharucha T;Pain CE;Jyothish D;Whittaker E;Dwarakanathan B;Wood R;Williams C;Swann O;Semple MG;Ramsay ME;Jones CE;Ramanan AV;Gent N;Ladhani SN
通讯作者：
Ladhani SN