Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity
Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity
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育亨宾诱导的去甲肾上腺素能激活降低了患有童年逆境的健康个体的内感受准确性
DOI：
10.1017/s0954579420001613
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发表时间：
2022
影响因子：
3.3
通讯作者：
Wingenfeld
中科院分区：
文献类型：
--
作者：
Schulz;Deuter;Breden;Vögele;Wingenfeld
急性应激影响内感受，但尚不清楚这是由于交感神经-肾上腺-髓质（SAM）或下丘脑-垂体-肾上腺皮质轴的激活。本研究旨在探讨SAM轴激活对内感受准确性（IAcc）的影响。中枢α 2-肾上腺素能受体代表SAM轴的负反馈机制。重度抑郁症和不良童年经历（ACE）与生物应激系统的改变有关，包括中枢α 2-肾上腺素能受体。在这里，有和没有ACE的健康个体以及有和没有ACE的抑郁患者（n = 114；所有没有抗抑郁药物）在服用育亨宾（α 2-肾上腺素能拮抗剂）和安慰剂后进行了测试。我们评估了心跳计数任务中的IAcc和敏感性。育亨宾后收缩压和舒张压升高证实SAM轴成功激活。服用育亨宾后，只有健康的ACE组IAcc降低，其他各组保持不变（组×药物相互作用）。这种影响可能是由于儿童创伤后α 2-肾上腺素能受体的选择性上调，从而降低了对心跳的注意力集中能力。包括α 2-肾上腺素能回路在内的交感神经通路可能是介导感觉间信号传递的必要条件。应激情境下身体感觉的抑制加工可能代表了经历ACE的健康个体的适应性反应。
Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamic–pituitary–adrenocortical axis. This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (n = 114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (Group × Drug interaction). This effect may be due to selective upregulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE.
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