Abnormalities of the Exocrine Pancreas in Type 1 Diabetes.
Abnormalities of the Exocrine Pancreas in Type 1 Diabetes.
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DOI：
10.1007/s11892-015-0653-y
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发表时间：
2015-10
影响因子：
4.2
通讯作者：
Battaglia, Manuela
中科院分区：
文献类型：
--
作者：
Campbell-Thompson, Martha;Rodriguez-Calvo, Teresa;Battaglia, Manuela
Type 1 diabetes (T1D) is considered a pancreatic beta cell-specific disease that results in absolute insulin deficiency. Nevertheless, clinical studies from 1940 onwards showed that patients with T1D had an abnormal exocrine pancreas due to the presence of subclinical exocrine insufficiency and acinar atrophy. Exocrine abnormalities are an important, and mostly neglected, characteristic associated with T1D. It is however still unclear whether the exocrine dysfunction in T1D is a primary damage caused by the same pathogenic event that led to beta cell destruction or secondary to beta cell loss. In this review, we collect evidence supporting the hypothesis that T1D is a combined endocrine-exocrine disease in which the loss of functional beta cell mass is most clinically apparent.
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影响因子：
24.5
作者：
FRIER, BM;SAUNDERS, JHB;BOUCHIER, IAD
通讯作者：
BOUCHIER, IAD
影响因子：
3.6
作者：
Hardt, PD;Hauenschild, A;Kloer, HU
通讯作者：
Kloer, HU
影响因子：
8.2
作者：
FOULIS, AK;LIDDLE, CN;WEIR, RS
通讯作者：
WEIR, RS
影响因子：
8
作者：
Ewald, N.;Kaufmann, C.;Hardt, P. D.
通讯作者：
Hardt, P. D.
影响因子：
15.9
作者：
Gaglia, Jason L.;Guimaraes, Alexander R.;Weissleder, Ralph
通讯作者：
Weissleder, Ralph