Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes.
Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes.
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DOI：
10.1002/hep.25741
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发表时间：
2012-09
期刊：
影响因子：
13.5
通讯作者：
Clark, Jeanne M.
中科院分区：
文献类型：
--
作者：
Abdelmalek, Manal F.;Lazo, Mariana;Horska, Alena;Bonekamp, Susanne;Lipkin, Edward W.;Balasubramanyam, Ashok;Bantle, John P.;Johnson, Richard J.;Diehl, Anna Mae;Clark, Jeanne M.
果糖摄入量预示着非酒精性脂肪性肝病 (NAFLD) 患者肝纤维化的增加。由于果糖能够降低肝三磷酸腺苷 (ATP) 水平，习惯性摄入果糖可能会导致更多的肝 ATP 消耗和 ATP 恢复受损。评估了低果糖消费者和高果糖消费者静脉注射果糖激发试验后 ATP 消耗的程度。我们评估了参加 Look AHEAD 脂肪肝辅助研究的糖尿病成人 (n=244)，通过 130 项食物频率调查问卷估算膳食果糖消耗量，并通过磷 MRS (31P MRS) 测量肝脏 ATP 和尿酸 (UA) 水平 (n=105)。在一部分参与者 (n=25) 中，利用静脉注射果糖挑战来评估肝脏 ATP 含量的变化。在低果糖（<15 g/d）和高果糖（≥15 g/d）消费者中评估了基线时和静脉注射果糖激发后膳食果糖、UA 和肝脏 ATP 消耗之间的关系。高膳食果糖消费者的基线肝脏 ATP 水平略低，并且静脉注射果糖挑战后肝脏 α-ATP/Pi 比率（0.08 vs. 0.03，p=0.05）和 γ-ATP/Pi 比率绝对变化较大（0.03 vs. 0.06，p=0.06）。高 UA (≥5.5 mg/dl) 的患者在果糖激发后表现出较低的最低肝脏 ATP/Pi 比率（4.5 vs. 7.0，p = 0.04）。高果糖消耗会消耗肝脏 ATP，并损害静脉注射果糖激发后从 ATP 消耗中恢复的能力。 UA 高的受试者对果糖的反应显示肝脏 ATP 的最低点更大。高膳食果糖摄入量和升高的 UA 水平可能预示着果糖引起的更严重的肝脏 ATP 耗竭，因此可能是 NAFLD 发生和进展的危险因素。
Fructose consumption predicts increased hepatic fibrosis in those with nonalcoholic fatty liver disease (NAFLD). Due to its ability to lower hepatic adenosine triphosphate (ATP) levels, habitual fructose consumption could result in more hepatic ATP depletion and impaired ATP recovery. The degree of ATP depletion following an intravenous fructose challenge test in low versus high fructose consumers was assessed. We evaluated diabetic adults enrolled in the Look AHEAD Fatty Liver Ancillary Study (n=244) for whom dietary fructose consumption estimated by a 130-item Food Frequency questionnaire, hepatic ATP measured by phosphorus MRS (31P MRS) and uric acid (UA) levels were performed (n=105). In a subset of participants (n=25), an intravenous fructose challenge was utilized to assess change in hepatic ATP content. The relationships between dietary fructose, UA and hepatic ATP depletion at baseline and following intravenous fructose challenge was evaluated in low (<15 g/d) vs. high (≥15 g/d) fructose consumers. High dietary fructose consumers had slightly lower baseline hepatic ATP levels and a greater absolute change in hepatic α-ATP/Pi ratio (0.08 vs. 0.03, p=0.05) and γ-ATP /Pi ratio following an intravenous fructose challenge (0.03 vs. 0.06, p=0.06). Patients with high UA (≥5.5 mg/dl) showed a lower minimum liver ATP/Pi ratio post-fructose challenge (4.5 vs. 7.0, p = 0.04). High fructose consumption depletes hepatic ATP and impairs recovery from ATP depletion following an intravenous fructose challenge. Subjects with high UA show a greater nadir in hepatic ATP in response to fructose. Both high dietary fructose intake and elevated UA level may predict more severe hepatic ATP depletion in response to fructose and hence may be risk factors for the development and progression of NAFLD.
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影响因子：
2.2
作者：
Gabr, RE;Ouwerkerk, R;Bottomley, PA
通讯作者：
Bottomley, PA
影响因子：
25.7
作者：
Li, Youming;Xu, Chengfu;Miao, Min
通讯作者：
Miao, Min
影响因子：
19.7
作者：
MEYERHOFF, DJ;BOSKA, MD;WEINER, MW
通讯作者：
WEINER, MW
影响因子：
13.5
作者：
Abdelmalek, Manal F.;Suzuki, Ayako;Guy, Cynthia;Unalp-Arida, Aynur;Colvin, Ryan;Johnson, Richard J.;Diehl, Anna Mae
通讯作者：
Diehl, Anna Mae
影响因子：
25.7
作者：
Ouyang, Xiaosen;Cirillo, Pietro;Abdelmalek, Manal F.
通讯作者：
Abdelmalek, Manal F.