Gut hormones, appetite suppression and cachexia in patients with pulmonary TB.
Gut hormones, appetite suppression and cachexia in patients with pulmonary TB.
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DOI：
10.1371/journal.pone.0054564
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gilman RH
中科院分区：
文献类型：
--
作者：
Chang SW;Pan WS;Lozano Beltran D;Oleyda Baldelomar L;Solano MA;Tuero I;Friedland JS;Torrico F;Gilman RH
恶病质是肺结核的一个特征，与预后不良有关。更好地了解这种减肥背后的机制可能会揭示治疗干预的目标。食欲调节激素在结核病中的作用尚不清楚。对41例初诊肺结核患者与82例健康体检者进行对照研究。我们测量了所有受试者的食欲、体重指数(BMI)、体脂百分比(BF)、血浆肽YY(PYY)、瘦素、Ghrelin和抵抗素。对照组在基线，病例在治疗第0、30和60天进行测量。患者的基线食欲、BMI和BF低于对照组，并在治疗过程中有所改善。PYY、Ghrelin和抵抗素在病例中显著升高，并在治疗过程中下降。瘦素在病例中较低，随着治疗的进行而上升。食欲与PYY呈负相关。治疗前高PYY预测食欲和BF增加减少。在所有时间点上，PYY是最强的食欲独立预测因子。结核病患者的食欲调节荷尔蒙发生了变化。随着荷尔蒙在治疗期间恢复正常，食欲恢复，营养状况得到改善。高基线PYY是治疗期间食欲和营养改善的预后不良的指标。结核病患者的消瘦可能部分是通过上调PYY，从而抑制食欲来调节的。
Cachexia is a hallmark of pulmonary tuberculosis and is associated with poor prognosis. A better understanding of the mechanisms behind such weight loss could reveal targets for therapeutic intervention. The role of appetite-regulatory hormones in tuberculosis is unknown. 41 subjects with newly-diagnosed pulmonary TB (cases) were compared to 82 healthy controls. We measured appetite, body mass index (BMI), % body fat (BF), plasma peptide YY (PYY), leptin, ghrelin, and resistin for all subjects. Measurements were taken at baseline for controls and at treatment days 0, 30, and 60 for cases. Baseline appetite, BMI, and BF were lower in cases than in controls and improved during treatment. PYY, ghrelin, and resistin were significantly elevated in cases and fell during treatment. Leptin was lower in cases and rose with treatment. Appetite was inversely related to PYY in cases. High pre-treatment PYY predicted reduced gains in appetite and BF. PYY was the strongest independent predictor of appetite in cases across all time points. Appetite-regulatory hormones are altered in TB patients. As hormones normalize during treatment, appetite is restored and nutritional status improves. High baseline PYY is an indicator of poor prognosis for improvement in appetite and nutrition during treatment. Wasting in TB patients may partly be mediated by upregulation of PYY with resulting appetite suppression.
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影响因子：
6.3
作者：
Kim, Ji Hae;Lee, Choon-Taek;Lee, Jae Ho
通讯作者：
Lee, Jae Ho
影响因子：
1.2
作者：
Moschovi, Maria;Trimis, Georgios;Tzortzatou-Stathopoulou, Fotini
通讯作者：
Tzortzatou-Stathopoulou, Fotini
影响因子：
4.6
作者：
Buyukoglan H;Gulmez I;Kelestimur F;Kart L;Oymak FS;Demir R;Ozesmi M
通讯作者：
Ozesmi M
影响因子：
--
作者：
Sacks, LV;Pendle, S
通讯作者：
Pendle, S
DOI：
10.1164/rccm.200310-1404oc
发表时间：
2004-10-15
影响因子：
24.7
作者：
Itoh, T;Nagaya, N;Kimura, H
通讯作者：
Kimura, H