Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review.
Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review.
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DOI：
10.1155/2010/513948
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发表时间：
2010
影响因子：
4.6
通讯作者：
Fain JN
中科院分区：
文献类型：
--
作者：
Fain JN
本文考虑了假定的脂肪因子的作用，它可能参与了肥胖中人类脂肪组织炎症反应的增强。炎性脂肪因子[IL-6、IL-10、ACE、tgf - β1、tnf - α、IL-1β、PAI-1和IL-8]和一种抗炎脂肪因子[IL-10]在肥胖中循环水平和体外脂肪释放增强，主要由人类脂肪组织的非脂肪细胞释放。相反，瘦素和FABP-4的循环水平也在肥胖中增加，它们主要由人体脂肪组织的脂肪细胞释放。综述了脂肪因子和其他蛋白质在人类大网膜中相对于皮下脂肪组织的表达，以及它们在人类大网膜脂肪组织中的非脂肪细胞和脂肪细胞中的表达。结论是，在肥胖人群中，脂肪组织释放的许多炎性脂肪因子会增加。
This paper considers the role of putative adipokines that might be involved in the enhanced inflammatory response of human adipose tissue seen in obesity. Inflammatory adipokines [IL-6, IL-10, ACE, TGFβ1, TNFα, IL-1β, PAI-1, and IL-8] plus one anti-inflammatory [IL-10] adipokine were identified whose circulating levels as well as in vitro release by fat are enhanced in obesity and are primarily released by the nonfat cells of human adipose tissue. In contrast, the circulating levels of leptin and FABP-4 are also enhanced in obesity and they are primarily released by fat cells of human adipose tissue. The relative expression of adipokines and other proteins in human omental as compared to subcutaneous adipose tissue as well as their expression in the nonfat as compared to the fat cells of human omental adipose tissue is also reviewed. The conclusion is that the release of many inflammatory adipokines by adipose tissue is enhanced in obese humans.
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DOI：
10.1016/j.gloenvcha.2003.10.004
发表时间：
2004-04-01
影响因子：
8.9
作者：
Arnell, NW;Livermore, MJL;Gaffin, SR
通讯作者：
Gaffin, SR
影响因子：
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DOI：
10.1152/ajpendo.00269.2003
发表时间：
2004-01-01
影响因子：
5.1
作者：
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通讯作者：
Richelsen, B
影响因子：
11.1
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