Near-IR responsive nanostructures for nanobiophotonics: emerging impacts on nanomedicine.

Near-IR responsive nanostructures for nanobiophotonics: emerging impacts on nanomedicine.
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用于纳米生物光子学的近红外响应纳米结构:对纳米医学的新兴影响。

DOI:
10.1016/j.nano.2015.11.009
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发表时间:
2016-04
期刊:
Nanomedicine-Nanotechnology, Biology and Medicine
影响因子:
--
通讯作者:
Paras N Prasad
Paras N Prasad
中科院分区:
其他
文献类型:
--
作者:
Jun Song;Junle Qu;Mark T Swihart;Paras N Prasad

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纳米生物光子学是纳米科学、光子学和生物技术交叉的新兴领域。利用光与纳米结构的相互作用可以实现新型的生物成像,传感和光激活治疗,这可以对纳米医学产生重大影响。通过组织的低穿透性限制了可见光在纳米医学中的使用。近红外(NIR)光(~ 780-1100 nm)可以穿透更远,使自由空间输送到深层组织。本文综述了近红外光与纳米结构相互作用产生的三种效应:直接光活化效应、光热效应和光化学效应。直接光活化的应用包括使用NIR发射量子点、在NIR中具有局部表面等离子体共振(LSPR)的材料和上转换纳米颗粒的生物成像和生物传感。使用光热效应的两个关键纳米医学应用是光热治疗(PTT)和光声(PA)成像。对于光化学效应,我们介绍了用于光动力疗法(PDT)的近红外激活的原位上转换和上转换纳米结构的最新进展。来自临床编辑Nanobiphotonics是一个相对较新的领域,将光应用于与纳米结构的相互作用,可用于生物成像,传感和治疗。由于近红外(NIR)光(~780-1100 nm)可以具有更好的组织穿透性,因此其临床潜力更大。本文综述了近红外光在医学成像和治疗中的应用。
Nanobiophotonics is an emerging field at the intersection of nanoscience, photonics, and biotechnology. Harnessing interactions of light with nanostructures enables new types of bioimaging, sensing, and light-activated therapy which can make a major impact on nanomedicine. Low penetration through tissue limits the use of visible light in nanomedicine. Near infrared (NIR) light (~ 780-1100 nm) can penetrate significantly further, enabling free-space delivery into deep tissues. This review focuses on interactions of NIR light with nanostructures to produce three effects: direct photoactivation, photothermal effects, and photochemical effects. Applications of direct photoactivation include bioimaging and biosensing using NIR-emitting quantum dots, materials with localized surface plasmon resonance (LSPR) in the NIR, and upconverting nanoparticles. Two key nanomedicine applications using photothermal effects are photothermal therapy (PTT), and photoacoustic (PA) imaging. For photochemical effects, we present the latest advances inin-situupconversion and upconverting nanostructures for NIR activation of photodynamic therapy (PDT).From the Clinical EditorNanobiophotonics is a relatively new field applying light for the interactions with nanostructures, which can be used in bioimaging, sensing, and therapy. As near infrared (NIR) light (~780-1100 nm) can have better tissue penetration, its clinical potential is far greater. In this review, the authors discussed the latest research on the applications of NIR light in imaging and therapeutics.
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