Migraine disability, pain catastrophizing, and headache severity are associated with evoked pain and targeted by mind-body therapy.
Migraine disability, pain catastrophizing, and headache severity are associated with evoked pain and targeted by mind-body therapy.
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DOI：
10.1097/j.pain.0000000000002578
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发表时间：
2022-09-01
期刊：
影响因子：
7.4
通讯作者：
中科院分区：
文献类型：
--
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荟萃分析表明，偏头痛患者对实验诱发的疼痛并不比健康对照组更敏感。与此同时，研究已经将一些偏头痛症状与定量感觉测试（QST）特征联系起来。不幸的是，以前的研究偏头痛症状和QST有重要的方法上的缺陷，源于小样本量，和频繁使用单变量统计的多变量研究问题。在目前的研究中，我们试图解决这些局限性，通过使用一个大样本的发作性偏头痛患者（n=103）和多变量分析，关联疼痛评级从许多热强度同时与12个临床措施，从头痛频率到睡眠异常。我们确定了热QST和偏头痛症状之间的关联，涉及所有刺激强度的疼痛评级和偏头痛症状的一个子集，与残疾（头痛影响测试6和简明疼痛量表干扰），灾难化（疼痛灾难化量表）和疼痛严重程度（平均头痛，简明疼痛量表严重程度和简明麦吉尔疼痛问卷2）。头痛频率、异常性疼痛、情感和睡眠障碍与这一维度无关。与以前的研究一致，我们没有观察到偏头痛患者和健康对照组之间的QST评分有任何差异。此外，我们发现，与QST相关的症状的线性组合被身心疗法增强的正念减压（MBSR+）所改变。这些结果表明，QST与疼痛症状有选择性的关系，即使在没有慢性疼痛患者和健康对照之间的差异。
Meta-analysis suggests migraine patients are no more sensitive to experimentally evoked pain than healthy controls. At the same time, studies have linked some migraine symptoms to Quantitative Sensory Testing (QST) profiles. Unfortunately, previous studies associating migraine symptoms and QST have important methodological shortcomings, stemming from small sample sizes, and frequent use of univariate statistics for multivariate research questions. In the current study we seek to address these limitations by using a large sample of episodic migraine patients (n=103) and a multivariate analysis that associates pain ratings from many thermal intensities simultaneously with 12 clinical measures ranging from headache frequency to sleep abnormalities. We identified a single dimension of association between thermal QST and migraine symptoms that relates to pain ratings for all stimulus intensities and a subset of migraine symptoms relating to disability (Headache Impact Test 6 and Brief Pain Inventory interference), catastrophizing (Pain Catastrophizing Scale), and pain severity (average headache pain, Brief Pain Inventory severity, and Short Form McGill Pain Questionnaire 2). Headache frequency, allodynia, affect, and sleep disturbances were unrelated to this dimension. Consistent with previous research, we did not observe any difference in QST ratings between migraine patients and healthy controls. Additionally, we found that the linear combination of symptoms that related to QST were modified by the mind-body therapy enhanced mindfulness-based stress reduction (MBSR+). These results suggest that QST has a selective relationship with pain symptoms even in the absence of between-subjects differences between chronic pain patients and healthy controls.
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影响因子：
7.4
作者：
Burrowes SAB;Goloubeva O;Stafford K;McArdle PF;Goyal M;Peterlin BL;Haythornthwaite JA;Seminowicz DA
通讯作者：
Seminowicz DA
影响因子：
1.6
作者：
Lin YK;Lin GY;Lee JT;Lee MS;Tsai CK;Hsu YW;Lin YZ;Tsai YC;Yang FC
通讯作者：
Yang FC
影响因子：
4.6
作者：
Mihalik, Agoston;Ferreira, Fabio S.;Mourao-Miranda, Janaina
通讯作者：
Mourao-Miranda, Janaina
影响因子：
5.3
作者：
Baliki, Marwan N.;Chialvo, Dante R.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
4
作者：
Finan, Patrick H.;Goodin, Burel R.;Smith, Michael T.
通讯作者：
Smith, Michael T.