Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers.
Task-dependent effects of nicotine treatment on auditory performance in young-adult and elderly human nonsmokers.
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尼古丁治疗对非吸烟成年人和老年人听觉表现的任务依赖性影响。
DOI：
10.1038/s41598-021-92588-z
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发表时间：
2021-06-23
影响因子：
4.6
通讯作者：
Zeng FG
中科院分区：
文献类型：
--
作者：
Sun S;Kapolowicz MR;Richardson M;Metherate R;Zeng FG
电生理学研究表明，尼古丁增强神经对特征频率刺激的反应。以前的行为研究部分证实了这些发现在年轻人中，表明尼古丁选择性地增强了在困难的听力条件下的听觉处理。目前的工作扩展了以前的工作，包括年轻人和老年人，并评估了尼古丁对声音频率和强度的影响。假设尼古丁改善了听觉表现，并且改善程度与基线表现成反比。在单盲、随机交叉设计中，听力正常的年轻（19-23岁）非吸烟者和听力正常在500 Hz至2000 Hz之间的老年（61-80岁）非吸烟者接受尼古丁咀嚼胶（6 mg）或安慰剂咀嚼胶。参与者在治疗前后进行了三个实验（频率辨别，调频识别和强度辨别）。分析了治疗前和治疗后之间以及治疗后尼古丁和安慰剂条件之间的感知差异，作为治疗前基线表现的函数。与预处理性能相比，尼古丁显着改善频率辨别。与安慰剂相比，尼古丁显著改善了强度辨别的表现，并且在基线表现较低的老年人中改善更为明显。尼古丁对调频识别没有影响。尼古丁的作用是任务依赖性的，反映了主题，任务和神经机制可能的相互作用。
Electrophysiological studies show that nicotine enhances neural responses to characteristic frequency stimuli. Previous behavioral studies partially corroborate these findings in young adults, showing that nicotine selectively enhances auditory processing in difficult listening conditions. The present work extended previous work to include both young and older adults and assessed the nicotine effect on sound frequency and intensity discrimination. Hypotheses were that nicotine improves auditory performance and that the degree of improvement is inversely proportional to baseline performance. Young (19–23 years old) normal-hearing nonsmokers and elderly (61–80) nonsmokers with normal hearing between 500 and 2000 Hz received nicotine gum (6 mg) or placebo gum in a single-blind, randomized crossover design. Participants performed three experiments (frequency discrimination, frequency modulation identification, and intensity discrimination) before and after treatment. The perceptual differences were analyzed between pre- and post-treatment, as well as between post-treatment nicotine and placebo conditions as a function of pre-treatment baseline performance. Compared to pre-treatment performance, nicotine significantly improved frequency discrimination. Compared to placebo, nicotine significantly improved performance for intensity discrimination, and the improvement was more pronounced in the elderly with lower baseline performance. Nicotine had no effect on frequency modulation identification. Nicotine effects are task-dependent, reflecting possible interplays of subjects, tasks and neural mechanisms.
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影响因子：
3.4
作者：
Pham, Carol Q.;Kapolowicz, Michelle R.;Zeng, Fan-Gang
通讯作者：
Zeng, Fan-Gang
影响因子：
3.4
作者：
Levin, ED;Conners, CK;Rose, JE
通讯作者：
Rose, JE
影响因子：
2.8
作者：
Harkrider, AW;Hedrick, MS
通讯作者：
Hedrick, MS
影响因子：
2.7
作者：
Horst, Nicole K.;Heath, Christopher J.;Picciotto, Marina R.
通讯作者：
Picciotto, Marina R.
影响因子：
4.7
作者：
Knott, Verner J.;Bolton, Kiley;Villeneuve, Crystal
通讯作者：
Villeneuve, Crystal