Bioprinting of skin constructs for wound healing.

Bioprinting of skin constructs for wound healing.
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皮肤构建体的生物打印用于伤口愈合。

DOI:
10.1186/s41038-017-0104-x
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发表时间:
2018
期刊:
影响因子:
5.3
通讯作者:
Li X
Li X
中科院分区:
医学2区
文献类型:
--
作者:
He P;Zhao J;Zhang J;Li B;Gou Z;Gou M;Li X

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大面积烧伤和全层皮肤伤口很难修复。自体中厚皮片(ASSG)仍是临床上的金标准。然而,供体皮肤组织的短缺是一个严重的问题。这一问题的一个潜在解决方案是使用带或不带细胞的生物材料支架来构建皮肤结构。生物印花被应用于解决适合移植的皮肤组织的需求,并可导致用于伤口愈合治疗的皮肤等价物的开发。在这里,我们总结了生物打印的策略,并回顾了当前生物打印皮肤结构的进展。3D生物打印在皮肤再生方面将面临挑战,但我们仍然相信,在可预见的未来,生物打印将成为伤口愈合的潜在技术。
Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the need for skin tissues suitable for transplantation, and can lead to the development of skin equivalents for wound healing therapy. Here, we summarize strategies of bioprinting and review current advances of bioprinting of skin constructs. There will be challenges on the way of 3D bioprinting for skin regeneration, but we still believe bioprinting will be potential skills for wounds healing in the foreseeable future.
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