Higher magnesium intake reduces risk of impaired glucose and insulin metabolism and progression from prediabetes to diabetes in middle-aged americans.
Higher magnesium intake reduces risk of impaired glucose and insulin metabolism and progression from prediabetes to diabetes in middle-aged americans.
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DOI：
10.2337/dc13-1397
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发表时间：
2014-02
期刊：
影响因子：
16.2
通讯作者：
McKeown NM
中科院分区：
文献类型：
--
作者：
Hruby A;Meigs JB;O'Donnell CJ;Jacques PF;McKeown NM
评估镁摄入量与前驱糖尿病和/或胰岛素抵抗（IR）以及从这些状态发展为2型糖尿病之间的7年相关性。在2582名26-81岁的社区居民中，镁摄入量和发生“代谢障碍”的风险，在基线状态正常的人群中估计空腹血糖（FG）受损（≥5.6至<7.0 mmol/L）、糖耐量受损（负荷后2小时葡萄糖≥7.8至<11.1 mmol/L）、IR或高胰岛素血症（分别为IR或空腹胰岛素稳态模型评估≥90百分位数），并在基线代谢损伤的人群中估计发生糖尿病的风险。在没有发生糖尿病的参与者中，我们检查了镁摄入量与禁食和负荷后葡萄糖和胰岛素、IR和胰岛素敏感性7年变化的关系。在调整了年龄、性别和能量摄入后，与最低镁摄入量者相比，最高镁摄入量者发生代谢损伤的风险降低37% (P趋势= 0.02)，而在基线代谢损伤者中，高镁摄入量者发生糖尿病的风险降低32% （P趋势= 0.05）。在综合人群中，最高摄取量者的风险为最低摄取量者的53% （P趋势= 0.0004）。对危险因素和膳食纤维进行调整后，基线正常人群的相关性减弱，但对代谢受损人群的相关性没有实质性影响。较高的镁摄入量往往与较低的随访FG和IR相关，但与空腹胰岛素、负荷后值或胰岛素敏感性无关。镁的摄入可能特别有利于抵消高风险人群患糖尿病的风险。镁与非稳态（动态）测量的长期联系值得进一步研究。
To assess 7-year associations between magnesium intake and incident prediabetes and/or insulin resistance (IR), and progression from these states to type 2 diabetes. In 2,582 community-dwelling participants 26–81 years old at baseline, magnesium intake and risk of incident “metabolic impairment,” defined as impaired fasting glucose (FG) (≥5.6 to <7.0 mmol/L), impaired glucose tolerance (2-h postload glucose ≥7.8 to <11.1 mmol/L), IR, or hyperinsulinemia (≥90th percentile of homeostasis model assessment of IR or fasting insulin, respectively), was estimated among those with normal baseline status, and risk of incident diabetes was estimated among those with baseline metabolic impairment. In participants without incident diabetes, we examined magnesium intake in relation to 7-year changes in fasting and postload glucose and insulin, IR, and insulin sensitivity. After adjusting for age, sex, and energy intake, compared with those with the lowest magnesium intake, those with the highest intake had 37% lower risk of incident metabolic impairment (P trend = 0.02), and in those with baseline metabolic impairment, higher intake was associated with 32% lower risk of incident diabetes (P trend = 0.05). In the combined population, the risk in those with the highest intake was 53% (P trend = 0.0004) of those with the lowest intake. Adjusting for risk factors and dietary fiber attenuated associations in the baseline normal population but did not substantially affect associations in the metabolically impaired. Higher magnesium intake tended to associate with lower follow-up FG and IR, but not fasting insulin, postload values, or insulin sensitivity. Magnesium intake may be particularly beneficial in offsetting risk of developing diabetes among those at high risk. Magnesium’s long-term associations with non–steady-state (dynamic) measures deserve further research.
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影响因子：
7.2
作者：
Guerrero-Romero, F;Tamez-Perez, HE;Rodríguez-Morán, M
通讯作者：
Rodríguez-Morán, M
DOI：
10.1080/07315724.2006.10719563
发表时间：
2006-12-01
影响因子：
3.5
作者：
Rumawas, Marcella E.;McKeown, Nicola M.;Jacques, Paul F.
通讯作者：
Jacques, Paul F.
影响因子：
--
作者：
KANNEL, WB;SORLIE, P
通讯作者：
SORLIE, P
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC
影响因子：
3.9
作者：
Barbagallo, Mario;Dominguez, Ligia J.
通讯作者：
Dominguez, Ligia J.