The alliance of genome resources: transforming comparative genomics.
The alliance of genome resources: transforming comparative genomics.
复制标题
基因组资源的联盟：改变比较基因组学。
DOI：
10.1007/s00335-023-10015-2
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发表时间：
2023-12
期刊：
影响因子：
2.5
通讯作者：
Sternberg, Paul W.
中科院分区：
文献类型：
--
作者：
Bult, Carol J.;Sternberg, Paul W.
比较多个物种的基因组和生物学特征对于使用模型系统研究人类生物学和疾病的分子和细胞机制以及将模型生物研究的机制见解转化为临床应用至关重要。基因组资源联盟（联盟）的首要使命是建立一个可扩展的知识共享平台，支持对模式生物和人类可用的有关基因功能、表型和疾病关联的丰富且专业的知识进行跨物种比较。该联盟是由七个模式生物知识库（小鼠、大鼠、酵母、线虫、斑马鱼、青蛙、果蝇）和基因本体资源组成的联盟。该联盟使用一组通用的基因直系同源断言作为比较联盟中代表的生物体的生物注释的基础。联盟数据库中目前与基因相关的主要知识类型包括基因功能、表型等位基因和变异、人类疾病关联、途径、基因表达以及蛋白质与蛋白质和遗传相互作用。该联盟通过实施共享程序访问机制、具有统一“外观和感觉”的特定数据网页以及专门为支持比较生物学而设计的交互式用户界面，增强了研究人员轻松比较模型生物和人类常见数据类型的生物注释的能力。联盟开发的模块化基础设施使资源能够充当可扩展的“知识共享区”，能够扩展以容纳更多的模型生物体。
Comparing genomic and biological characteristics across multiple species is essential to using model systems to investigate the molecular and cellular mechanisms underlying human biology and disease and to translate mechanistic insights from studies in model organisms for clinical applications. Building a scalable knowledge commons platform that supports cross-species comparison of rich, expertly curated knowledge regarding gene function, phenotype, and disease associations available for model organisms and humans is the primary mission of the Alliance of Genome Resources (the Alliance). The Alliance is a consortium of seven model organism knowledgebases (mouse, rat, yeast, nematode, zebrafish, frog, fruit fly) and the Gene Ontology resource. The Alliance uses a common set of gene ortholog assertions as the basis for comparing biological annotations across the organisms represented in the Alliance. The major types of knowledge associated with genes that are represented in the Alliance database currently include gene function, phenotypic alleles and variants, human disease associations, pathways, gene expression, and both protein–protein and genetic interactions. The Alliance has enhanced the ability of researchers to easily compare biological annotations for common data types across model organisms and human through the implementation of shared programmatic access mechanisms, data-specific web pages with a unified “look and feel”, and interactive user interfaces specifically designed to support comparative biology. The modular infrastructure developed by the Alliance allows the resource to serve as an extensible “knowledge commons” capable of expanding to accommodate additional model organisms.
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影响因子：
12.3
作者：
Buels R;Yao E;Diesh CM;Hayes RD;Munoz-Torres M;Helt G;Goodstein DM;Elsik CG;Lewis SE;Stein L;Holmes IH
通讯作者：
Holmes IH
影响因子：
12.3
作者：
McLaren W;Gil L;Hunt SE;Riat HS;Ritchie GR;Thormann A;Flicek P;Cunningham F
通讯作者：
Cunningham F
影响因子：
3.3
作者：
Gramates LS;Agapite J;Attrill H;Calvi BR;Crosby MA;Dos Santos G;Goodman JL;Goutte-Gattat D;Jenkins VK;Kaufman T;Larkin A;Matthews BB;Millburn G;Strelets VB;the FlyBase Consortium
通讯作者：
the FlyBase Consortium
影响因子：
14.9
作者：
Gillespie M;Jassal B;Stephan R;Milacic M;Rothfels K;Senff-Ribeiro A;Griss J;Sevilla C;Matthews L;Gong C;Deng C;Varusai T;Ragueneau E;Haider Y;May B;Shamovsky V;Weiser J;Brunson T;Sanati N;Beckman L;Shao X;Fabregat A;Sidiropoulos K;Murillo J;Viteri G;Cook J;Shorser S;Bader G;Demir E;Sander C;Haw R;Wu G;Stein L;Hermjakob H;D'Eustachio P
通讯作者：
D'Eustachio P
影响因子：
10.7
作者：
Priyann, Anurag;Woodcroft, Ben J.;Wurm, Yannick
通讯作者：
Wurm, Yannick