Pattern of hippocampal shape and volume differences in blind subjects.
Pattern of hippocampal shape and volume differences in blind subjects.
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DOI：
10.1016/j.neuroimage.2009.01.071
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发表时间：
2009-07-15
期刊：
影响因子：
5.7
通讯作者：
Thompson PM
中科院分区：
文献类型：
--
作者：
Leporé N;Shi Y;Lepore F;Fortin M;Voss P;Chou YY;Lord C;Lassonde M;Dinov ID;Toga AW;Thompson PM
在动物和人类中的大量研究表明，海马（HP）参与空间导航和记忆。特别是盲人，他们必须记住大量的信息，以弥补他们缺乏即时更新的空间信息。对空间认知和记忆的需求增加可能与功能和结构HP可塑性有关。在这里，我们研究了当地的大小和形状的差异，在HP的盲人和视力正常的人。基于22名盲人和28名匹配对照的3D体积T1加权MR图像的手动分割，生成3D参数网格表面以代表每个个体的右侧和左侧HP。使用中描述的新表面映射算法，我们为对照组创建了一个平均海马表面，并计算其到每个表面的正常距离。创建统计图以可视化组间的系统解剖学差异，并进行随机化检验以校正多重比较。还绘制了p值的累积分布函数，以检查海马数据和针对脑尺度差异调整的数据中的组差异幅度。在缩放和未缩放的数据中，盲人的右前HP显着更大，而右后HP显着更小。左侧HP无显著差异。这些差异可能反映了对感觉剥夺的适应性反应，和/或对记忆系统的功能需求增加。它们为未来与导航性能或与认知策略变化相关的功能激活的相关性提供了神经解剖学基础。
Numerous studies in animals and humans have shown that the hippocampus (HP) is involved in spatial navigation and memory. Blind subjects, in particular, must memorize extensive information to compensate for their lack of immediate updating of spatial information. Increased demands on spatial cognition and memory may be associated with functional and structural HP plasticity. Here we examined local size and shape differences in the HP of blind and sighted individuals. A 3D parametric mesh surface was generated to represent right and left HPs in each individual, based on manual segmentations of 3D volumetric T1- weighted MR images of 22 blind subjects and 28 matched controls. Using a new surface mapping algorithm described in, we created an average hippocampal surface for the controls, and computed its normal distance to each individual surface. Statistical maps were created to visualize systematic anatomical differences between groups, and randomization tests were performed to correct for multiple comparisons. Cumulative distribution functions for the p -values were also plotted to examine the magnitude of group differences in hippocampal data, and in data adjusted for brain scale differences. In both scaled and unscaled data, the anterior right HP was significantly larger, and the posterior right HP significantly smaller in blind individuals. No significant differences were found for left HP. These differences may reflect adaptive responses to sensory deprivation, and/or increased functional demands on memory systems. They offer a neuroanatomical substrate for future correlations with measures of navigation performance or functional activations related to variations in cognitive strategies.
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