Community and household-level socioeconomic disadvantage and functional organization of the salience and emotion network in children and adolescents.
Community and household-level socioeconomic disadvantage and functional organization of the salience and emotion network in children and adolescents.
复制标题
DOI：
10.1016/j.neuroimage.2018.09.077
复制
发表时间：
2019-01-01
期刊：
影响因子：
5.7
通讯作者：
Rabinak CA
中科院分区：
文献类型：
--
作者：
Gellci K;Marusak HA;Peters C;Elrahal F;Iadipaolo AS;Rabinak CA
儿童时期的社会经济劣势与身心健康方面的差异有关。越来越多的研究集中在确定SED的神经发育后果，通常使用家庭内因素（例如，家庭收入），以更好地了解与可持续发展相关的差异的潜在过程。这些研究表明，儿童SED对大脑发育有广泛的影响，同时改变多个大脑区域的发育。这些发现也提高了儿童SED影响关键大脑系统的发展的可能性，例如显着性和情感网络（SEN），它位于参与认知和情感相关功能的大脑系统的交叉点，并被认为是这些网络内部和之间的信息流的中介。本研究测试家庭和社区一级的SED之间的关联，以及它们的相互作用，并在57名儿童和青少年（6-17岁）的SEN为基础的功能性神经组织的措施。我们将图论分析应用于静息态功能磁共振成像（fMRI），以检查基于SEN的功能网络拓扑结构。结果显示，居住在更贫困社区的青年表现出较低的枢纽性质（即，更低效率的全球信息传递和更少的连接）的两个核心SEN节点-前扣带皮层和左侧缘上回。家庭收入对前扣带回的效率有相反的影响，但对边缘上回没有影响。然而，有收入和社区SED之间的相互作用，在吻侧前额叶皮层，这样，较高的收入与较高的聚类系数和较低的介数中心性，这表明更大的本地处理和较低的影响，该地区对整个网络的信息流。这些影响仅在生活在低（但不高）SED社区的青年中显着，这表明家庭内的SED因素可能无法抵御不利社区环境的不利影响。同样，与年龄相关的左喙前额叶皮层平均路径长度的增加只在生活在低（但不高）SED社区的年轻人中显着。鉴于SEN的成熟被认为是支持更灵活的认知和情感过程发展到成年的关键功能支柱，我们测试了SEN图指标与认知和情感相关功能测量之间的联系。我们发现，较高的社区SED和较低的收入都与较低的智商有关。智商较低，反过来，与左缘上回的整体效率有关。观察到的SED对基于SEN的功能性神经组织的影响可能有助于解释儿童SED与认知和情感结果差异之间的强烈和普遍联系。
Socioeconomic disadvantage (SED) during childhood has been linked to disparities in physical and mental health. A growing body of research has focused on identifying neurodevelopmental consequences of SED, commonly measured using within-household factors (e.g., household income), to better understand the processes underlying SED-related disparities. These studies suggest that childhood SED has a widespread impact on brain development, altering development of multiple brain regions simultaneously. These findings also raise the possibility that childhood SED impacts development of key brain systems, such as the salience and emotion network (SEN), which is positioned at the intersection of brain systems involved in cognitive and emotion-related functioning and is thought to mediate information flow within and between these networks. The present study tests for associations between household- and community-level SED, as well as their interaction, and measures of SEN-based functional neural organization in 57 children and adolescents (ages 6–17). We applied graph theoretical analyses to resting-state functional magnetic resonance imaging (fMRI) to examine SEN-based functional network topology. Results showed that youth residing in more distressed communities demonstrate lower hub-like properties (i.e., less efficient global information transfer and fewer connections) of two core SEN nodes – the anterior cingulate cortex and the left supramarginal gyrus. Household income had an opposite effect on efficiency of the anterior cingulate, but no effect on the supramarginal gyrus. There was, however, an interaction between income and community SED in the rostral prefrontal cortex, such that higher income was associated with higher clustering coefficient and lower betweenness centrality, suggesting greater local processing and lower influence of this region on information flow across the network. These effects were significant only among youth living in low (but not high) SED communities, suggesting that within-household SED factors may not protect against the detrimental effects of a disadvantaged community context. Similarly, the age-related increase in average path length of the left rostral prefrontal cortex was only significant among youth living in low (but not high) SED communities. Given that maturation of the SEN is considered to be a critical functional backbone supporting the development of more flexible cognitive and emotional processes into adulthood, we tested for links between SEN graph metrics and measures of cognitive and emotion-related functioning. We found that higher community SED and lower income were both associated with lower IQ. Lower IQ, in turn, was associated with global efficiency of the left supramarginal gyrus. Observed effects of SED on SEN-based functional neural organization may help to explain the strong and pervasive link between childhood SED and disparities in cognitive and emotional outcomes.
登录
查看更多内容
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
4.2
作者：
Gianaros, Peter J.;Horenstein, Jeffrey A.;Cohen, Sheldon
通讯作者：
Cohen, Sheldon
DOI：
10.1097/00004583-200109000-00009
发表时间：
2001-09-01
影响因子：
13.3
作者：
Durston, S;Pol, HEH;van Engeland, H
通讯作者：
van Engeland, H
影响因子：
5
作者：
Bosma, H;van de Mheen, HD;Mackenbach, JP
通讯作者：
Mackenbach, JP
DOI：
10.1111/j.0963-7214.2004.00286.x
发表时间：
2004-06-01
影响因子：
7.2
作者：
Chen, E
通讯作者：
Chen, E