Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation.
Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation.
复制标题
DOI：
10.1242/dmm.009837
复制
发表时间：
2012-09
影响因子：
4.3
通讯作者：
Finlayson G
中科院分区：
文献类型：
--
作者：
Blundell JE;Caudwell P;Gibbons C;Hopkins M;Naslund E;King N;Finlayson G
食欲研究中一个长期存在的问题是能量消耗对能量摄入的影响。 50多年前，Otto G. Edholm提出“[个体]食物摄入量的差异必定源于能量消耗的差异”。然而，尽管在两周内存在相关性，但无法发现任何一天内的能量消耗和能量摄入之间的关系。在对整合生物学的兴趣被分子生物化学取代之前，这个问题从未得到解决。我们利用心理生物学方法，对一组超重和肥胖的人类受试者使用多级实验系统，研究了能量平衡框架中的食欲控制。这揭示了身体成分[去脂体重（FFM）、脂肪质量（FM）]、新陈代谢、胃肠激素、饥饿和能量摄入等领域的变量之间的关系。在本评论中，我们回顾了我们自己的数据和其他数据，并讨论了一种新的配方，通过能量消耗来调节食欲控制和能量摄入。具体来说，我们提出FFM（静息代谢率的最大贡献者）而不是体重指数或FM，与自主决定的膳食量和每日能量摄入密切相关。该公式对于理解体重调节和肥胖管理具有重要意义。
A long-running issue in appetite research concerns the influence of energy expenditure on energy intake. More than 50 years ago, Otto G. Edholm proposed that “the differences between the intakes of food [of individuals] must originate in differences in the expenditure of energy”. However, a relationship between energy expenditure and energy intake within any one day could not be found, although there was a correlation over 2 weeks. This issue was never resolved before interest in integrative biology was replaced by molecular biochemistry. Using a psychobiological approach, we have studied appetite control in an energy balance framework using a multi-level experimental system on a single cohort of overweight and obese human subjects. This has disclosed relationships between variables in the domains of body composition [fat-free mass (FFM), fat mass (FM)], metabolism, gastrointestinal hormones, hunger and energy intake. In this Commentary, we review our own and other data, and discuss a new formulation whereby appetite control and energy intake are regulated by energy expenditure. Specifically, we propose that FFM (the largest contributor to resting metabolic rate), but not body mass index or FM, is closely associated with self-determined meal size and daily energy intake. This formulation has implications for understanding weight regulation and the management of obesity.
登录
查看更多内容
影响因子：
7.1
作者：
MAYER, J;ROY, P;MITRA, KP
通讯作者：
MITRA, KP
影响因子：
5.4
作者：
Keesey, Richard E.;Powley, Terry L.
通讯作者：
Powley, Terry L.
影响因子：
120.7
作者：
Church, Timothy S.;Earnest, Conrad P.;Blair, Steven N.
通讯作者：
Blair, Steven N.
影响因子：
3.6
作者：
EDHOLM, OG;FLETCHER, JG;MCCANCE, RA
通讯作者：
MCCANCE, RA
影响因子：
3.3
作者：
Broom, D. R.;Stensel, D. J.;Miyashita, M.
通讯作者：
Miyashita, M.