Role of microbes in the pathogenesis of neuropsychiatric disorders.

Role of microbes in the pathogenesis of neuropsychiatric disorders.
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DOI:
10.1016/j.yfrne.2021.100917
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发表时间:
2021-07
影响因子:
7.4
通讯作者:
Polimanti R
Polimanti R
中科院分区:
医学1区
文献类型:
--
作者:
Goswami A;Wendt FR;Pathak GA;Tylee DS;De Angelis F;De Lillo A;Polimanti R

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微生物栖息在人体的不同解剖部位,包括口腔、肠道和皮肤。越来越多的文献强调了微生物组变异如何与人类健康和疾病相关。有强有力的证据表明,肠道和大脑之间的双向通信由神经递质和微生物代谢产物介导。在这里,我们回顾了肠道和其他身体部位的微生物在八种神经精神疾病发病机制中的潜在参与,讨论了动物和人类研究的结果。报告的数据全面概述了神经精神病学中微生物组研究的现状,包括关于报告的相关机制以及益生菌和益生元的转化潜力的假设。
Microbes inhabit different anatomical sites of the human body including oral cavity, gut, and skin. A growing literature highlights how microbiome variation is associated with human health and disease. There is strong evidence of bidirectional communication between gut and brain mediated by neurotransmitters and microbial metabolites. Here, we review the potential involvement of microbes residing in the gut and in other body sites in the pathogenesis of eight neuropsychiatric disorders, discussing findings from animal and human studies. The data reported provide a comprehensive overview of the current state of the microbiome research in neuropsychiatry, including hypotheses about the mechanisms underlying the associations reported and the translational potential of probiotics and prebiotics.
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