Age-related changes in human trabecular bone: Relationship between microstructural stress and strain and damage morphology.
Age-related changes in human trabecular bone: Relationship between microstructural stress and strain and damage morphology.
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DOI：
10.1016/j.jbiomech.2011.05.034
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发表时间：
2011-08-11
影响因子：
2.4
通讯作者：
Guldberg, Robert E.
中科院分区：
文献类型：
--
作者：
Green, Jessica O.;Nagaraja, Srinidhi;Diab, Tamim;Vidakovic, Brani;Guldberg, Robert E.
衰老和疾病中微损伤的积累会导致骨骼脆弱，是导致骨质疏松性骨折的几个因素之一。为了更好地了解微损伤在脆性骨折中的作用，必须在组织水平上阐明骨衰竭的机制，同时检查骨基质特性、局部生物力学环境和骨结构之间的相互作用对微损伤形成的贡献。采用将单个小梁的组织学损伤评估与小梁 von Mises 的线性有限元解以及主应力和应变相结合的技术来比较绝经前（32-37 岁，n=3 供体）和绝经后（71-80 岁，n=3 供体）股骨尸体骨之间的损伤起始阈值。在两组中都观察到损伤形态与应力和应变参数之间存在很强的相关性，并且检测到未损伤小梁 von Mises 应力与年龄相关的下降。在年轻捐赠者的小梁中，未受损区域的 von Mises 应力的 95% CI 范围为 50.7 – 67.9 MPa，而在老年捐赠者的小梁中，应力显着较低 (38.7 – 50.2，p<0.01)。局部微结构分析表明，沿加载轴定向的较细的杆状小梁更容易在老年个体中形成严重的微损伤，而只有杆状结构与年轻个体的严重损伤相关。因此，这项研究深入了解了损伤萌生和形态与局部小梁微观结构以及负载下相关应力和应变的关系。此外，通过比较绝经前和绝经后女性的样本，结果表明，年轻个体的小梁可以在微损伤开始之前承受更高的压力。
Accumulation of microdamage in aging and disease can cause skeletal fragility and is one of several factors contributing to osteoporotic fractures. To better understand the role of microdamage in fragility fracture, the mechanisms of bone failure must be elucidated on a tissue-level scale where interactions between bone matrix properties, the local biomechanical environment, and bone architecture are concurrently examined for their contributions to microdamage formation. A technique combining histological damage assessment of individual trabeculae with linear finite element solutions of trabecular von Mises and principal stress and strain was used to compare the damage initiation threshold between pre-menopausal (32–37 years, n=3 donors) and post-menopausal (71–80 years, n=3 donors) femoral cadaveric bone. Strong associations between damage morphology and stress and strain parameters were observed in both groups, and an age-related decrease in undamaged trabecular von Mises stress was detected. In trabeculae from younger donors, the 95% CI for von Mises stress on undamaged regions ranged from 50.7 – 67.9 MPa, whereas in trabeculae from older donors, stresses were significantly lower (38.7 – 50.2, p<0.01). Local microarchitectural analysis indicated that thinner, rod-like trabeculae oriented along the loading axis are more susceptible to severe microdamage formation in older individuals, while only rod-like architecture was associated with severe damage in younger individuals. This study therefore provides insight into how damage initiation and morphology relate to local trabecular microstructure and the associated stresses and strains under loading. Furthermore, by comparison of samples from pre- and post-menopausal women, the results suggest that trabeculae from younger individuals can sustain higher stresses prior to microdamage initiation.
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DOI：
10.1016/0169-6009(90)90061-j
发表时间：
1990-11-01
期刊：
BONE AND MINERAL
影响因子：
--
作者：
KIMMEL, DB;RECKER, RR;ALOIA, JF
通讯作者：
ALOIA, JF
影响因子：
4.1
作者：
O'Neal, Jessica M.;Diab, Tamim;Allen, Matthew R.;Vidakovic, Brani;Burr, David B.;Guldberg, Robert E.
通讯作者：
Guldberg, Robert E.
影响因子：
4.1
作者：
Busse, Bjoern;Hahn, Michael;Amling, Michael
通讯作者：
Amling, Michael
影响因子：
4.1
作者：
Mori, S;Harruff, R;Burr, DB
通讯作者：
Burr, DB
影响因子：
4.2
作者：
Paschalis, EP;Betts, F;Boskey, AL
通讯作者：
Boskey, AL