Preoperative monocyte-to-HDL-cholesterol ratio predicts early recurrence after radiofrequency maze procedure of valvular atrial fibrillation.
Preoperative monocyte-to-HDL-cholesterol ratio predicts early recurrence after radiofrequency maze procedure of valvular atrial fibrillation.
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DOI：
10.1002/jcla.23595
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发表时间：
2021-03
影响因子：
2.7
通讯作者：
Wang D
中科院分区：
文献类型：
--
作者：
Adili A;Wang Y;Zhu X;Cao H;Fan F;Tang X;Zhou Q;Wang D
单核细胞与高密度脂蛋白（M/H）比值已成为一种新的心血管预后生物标志物。我们的目的是评估M/H与射频（RF）迷宫手术后早期复发的持续性瓣膜性心房颤动（AF）患者的预后价值。我们回顾性分析了131例持续性房颤合并心脏瓣膜病的患者，他们在射频迷宫手术后随访了3个月。记录其临床资料。Logistic回归分析进行了显着的预测因素。采用受试者工作特征分析法，以相应的曲线下面积进行验证。70例（53.4%）患者术后早期复发。早期复发的患者年龄较大，AF持续时间较长，左心房直径（LAD）较大，血浆C反应蛋白（CRP）较高，甘油三酯（TG）较低，胆固醇（TC）较低，单核细胞计数增加，HDL胆固醇较低，M/H比值增加。在多变量分析中，年龄（OR 1.1 95% CI 1.0 - 1.1 P = .003），LAD（OR 2.1，95%CI 1.2 - 3.5，P = .006），TG（OR 0.35，95% CI 0.15 - 0.84，P = 0.019），M/H（OR 6.1，95% CI 2.9 - 13.0，P <0.001）是房颤早期复发的显著独立预测因素。M/H比值显示出显著的预测值（AUC = 0.77，敏感性89.0%，特异性54%）。此外，M/H比值与CRP和白色血细胞呈正相关。术前M/H比值是RF迷宫术后AF早期复发的独立危险因素。M/H比值可作为瓣膜性房颤早期复发的预测指标。主线
Monocyte‐to‐high‐density lipoprotein (M/H) ratio has emerged as a novel cardiovascular prognostic biomarker. We aimed to evaluate the prognostic values of M/H with early recurrence in persistent valvular atrial fibrillation (AF) patients after radiofrequency (RF) maze procedure. We retrospectively analyzed 131 consecutive persistent AF patients with valvular heart diseases who were followed up 3 months after RF maze procedure. Their clinical data were recorded. Logistic regression analyses were performed for significant predictors. Receiver operating characteristic analysis was used for validation with corresponding area under the curve. 70 (53.4%) patients experienced early recurrence after procedure. Patients with early recurrence were older, have longer AF duration history, larger left atria diameter (LAD), higher plasma C‐reactive protein (CRP), lower triglycerides (TG), lower cholesterol (TC), increased monocyte counts, lower HDL cholesterol, and increased M/H ratio. In multivariate analysis, age (OR 1.1 95% CI 1.0‐1.1 P = .003), LAD (OR 2.1, 95%CI 1.2‐3.5, P = .006), TG (OR 0.35, 95% CI 0.15‐0.84, P = .019), M/H (OR 6.1, 95% CI 2.9‐13.0, P < .001) were significantly independent predictors of AF early recurrence. M/H ratio demonstrated a significant predictive value (AUC = 0.77, sensitivity 89.0%, specificity 54%). Further, there was a positive correlation of M/H ratio with CRP and white blood cell. Preoperative M/H ratio was an independent risk factor of AF early recurrence following RF maze operation. M/H ratio should be considered in prediction of early recurrence for valvular AF patients. Main Line.
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