Epidemiologic clues to SARS origin in China.

Epidemiologic clues to SARS origin in China.
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DOI:
10.3201/eid1006.030852
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发表时间:
2004-06
影响因子:
11.8
通讯作者:
Schnur A
Schnur A
中科院分区:
医学2区
文献类型:
--
作者:
Xu RH;He JF;Evans MR;Peng GW;Field HE;Yu DW;Lee CK;Luo HM;Lin WS;Lin P;Li LH;Liang WJ;Lin JY;Schnur A

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2002年11月,中国广东省佛山市爆发了严重急性呼吸系统综合征(SARS)疫情。我们研究了2003年4月30日之前的SARS病例报告,包括病例调查数据和索引病例的病例系列分析。共有1 454例临床确诊病例(55例死亡); 2003年2月第一周是疫情高峰期。医护人员占24%。儿童(<18岁)和老年人(>65岁)的临床体征和症状不同。一些观察结果支持SARS起源于野生动物的假设。病例明显独立发生在至少5个不同的城市;早期病例患者比晚期患者更可能报告居住在农产品市场附近(比值比未定义; 95%置信区间下限为2.39),但不靠近农场; 23例早期患者中有9例(39%)是可能与动物接触的食品处理人员,其中6例在佛山生活或工作。
An epidemic of severe acute respiratory syndrome (SARS) began in Foshan municipality, Guangdong Province, China, in November 2002. We studied SARS case reports through April 30, 2003, including data from case investigations and a case series analysis of index cases. A total of 1,454 clinically confirmed cases (and 55 deaths) occurred; the epidemic peak was in the first week of February 2003. Healthcare workers accounted for 24% of cases. Clinical signs and symptoms differed between children (<18 years) and older persons (>65 years). Several observations support the hypothesis of a wild animal origin for SARS. Cases apparently occurred independently in at least five different municipalities; early case-patients were more likely than later patients to report living near a produce market (odds ratio undefined; lower 95% confidence interval 2.39) but not near a farm; and 9 (39%) of 23 early patients, including 6 who lived or worked in Foshan, were food handlers with probable animal contact.
DOI: 10.1016/s0140-6736(03)13364-8
发表时间: 2003-05-17
期刊: Lancet (London, England)
影响因子: --
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