Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration.
Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration.
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DOI：
10.1080/15592294.2023.2165321
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发表时间：
2023-12
期刊：
影响因子：
3.7
通讯作者：
Felix, Janine F. F.
中科院分区：
文献类型：
--
作者：
Marques, Irene;Santos, Susana;Monasso, Giulietta S. S.;Fossati, Serena;Vrijheid, Martine;Nieuwenhuijsen, Mark;Jaddoe, Vincent W. V.;Felix, Janine F. F.
关键词：
早期生活被视为对环境暴露特别敏感的时期。怀孕期间的自然空间暴露与后代的健康有关。表观遗传胎龄加速（临床胎龄和基于DNA甲基化的胎龄之间的差异）可能是这些关联的基础。在1359对来自基于人群的R世代研究的母亲-新生儿中，我们研究了自然空间暴露的相关性，定义为周围的绿色，与主要绿色和蓝色（水）空间的距离，以及怀孕期间蓝色空间的大小与后代表观遗传胎龄加速的关系。自然空间暴露是基于参与者的地理编码地址，表观遗传胎龄加速是使用Bohlin和Knight的表观遗传时钟从脐带血DNA甲基化计算的。根据末次月经，在最佳妊娠日期的新生儿亚组中进行敏感性分析。周围的绿色，测量归一化差异植被指数值，是中间（中位数0.4，IQR 0.2），和84%和56%的参与者有一个主要的绿色或蓝色空间附近的家庭住址，分别。我们没有观察到怀孕期间自然空间的可用性与后代表观遗传胎龄加速的相关性。这可能意味着脐带血中的表观遗传胎龄加速并不构成妊娠期住宅自然空间可用性对后代健康影响的基础。未来的研究可以调查怀孕期间住宅自然空间的可用性是否与后代在其他CpG上的差异DNA甲基化有关，而不是表观遗传妊娠时钟中的CpG。
Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health. Epigenetic gestational age acceleration, a discrepancy between clinical and DNA methylation-based gestational age, may underlie these associations. In 1359 mother-newborn pairs from the population-based Generation R Study, we examined the associations of natural space exposure, defined as surrounding greenness, distance to major green and blue (water) space, and size of the blue space during pregnancy with offspring epigenetic gestational age acceleration. Natural space exposure was based on participants’ geocoded addresses, and epigenetic gestational age acceleration was calculated from cord blood DNA methylation using Bohlin’s and Knight’s epigenetic clocks. Sensitivity analyses were conducted in a subgroup of newborns with optimal pregnancy dating, based on last menstrual period. Surrounding greenness, measured in normalized difference vegetation index values, was intermediate (median 0.4, IQR 0.2), and 84% and 56% of the participants had a major green or blue space near their home address, respectively. We did not observe associations of natural space availability during pregnancy with offspring epigenetic gestational age acceleration. This could imply that epigenetic gestational age acceleration in cord blood does not underlie the effects of residential natural space availability in pregnancy on offspring health. Future studies could investigate whether residential natural space availability during pregnancy is associated with offspring differential DNA methylation at other CpGs than those included in the epigenetic gestational clocks.
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影响因子：
5.7
作者：
Dieckmann L;Lahti-Pulkkinen M;Kvist T;Lahti J;DeWitt PE;Cruceanu C;Laivuori H;Sammallahti S;Villa PM;Suomalainen-König S;Eriksson JG;Kajantie E;Raikkönen K;Binder EB;Czamara D
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DOI：
10.3390/ijerph18084092
发表时间：
2021-04-13
影响因子：
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作者：
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James P
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影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
DOI：
10.1186/1476-069x-11-42
发表时间：
2012-06-27
期刊：
Environmental health : a global access science source
影响因子：
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作者：
Barouki R;Gluckman PD;Grandjean P;Hanson M;Heindel JJ
通讯作者：
Heindel JJ
影响因子：
3.7
作者：
Chen, Li;Wagner, Carol L.;Zhu, Haidong
通讯作者：
Zhu, Haidong