An Effective and Safe Novel Treatment of Opioid Use Disorder: Unilateral Transcranial Photobiomodulation.
An Effective and Safe Novel Treatment of Opioid Use Disorder: Unilateral Transcranial Photobiomodulation.
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DOI：
10.3389/fpsyt.2021.713686
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发表时间：
2021
影响因子：
4.7
通讯作者：
Teicher MH
中科院分区：
文献类型：
--
作者：
Schiffer F;Khan A;Bolger E;Flynn E;Seltzer WP;Teicher MH
背景：即使在目前的治疗方法下，阿片类药物的流行也是一场全球性的悲剧，一种新颖、安全和有效的治疗方法将受到欢迎。我们在这里报告我们的第二个随机对照试验的结果，该试验评估单侧经颅光生物调节作为阿片类药物使用障碍的治疗方法。方法：我们在两个地点招募了39名有阿片类药物依赖的受试者，其中19人接受了主动治疗，其中19人接受了积极治疗，包括在810 nm处照射一支发光二极管，每周两次，每次4分钟，照射强度为250 mW/cm2，照射剂量为60J/cm2，照射范围为左侧或右侧前额叶背外侧皮质，对大脑的照射强度为2.1J/cm2。20名参与者接受了相同设备的假治疗，灯泡上覆盖着锡箔。治疗的一方是基于双脑心理学，该理论假设一个大脑半球比另一个大脑半球更容易受到过去虐待的影响，更容易出现焦虑和药物渴望。我们对大脑半球进行了两次HEV测试，以获得更积极的大脑半球情感价值(HEV)。结果：我们的主要结果是治疗前阿片类药物渴求量表(OCS)减去基线的变化，我们使用混合模型发现，活动组比假手术组有非常显著的治疗时间益处，p<；0.0001，最后一次随访的效果大小为1.5%。积极的治疗使那些没有服用丁丙诺啡的人以及那些没有服用丁丙诺啡的人受益。积极治疗组阿片类药物使用的时间线跟踪测量明显更好，p=0.0001，效果大小为0.45%。我们没有观察到不良反应。结论：在两个独立的随机对照试验中，HEV较好的单侧大脑半球主动单侧光生物调节在减少阿片类药物渴求和阿片类药物使用方面优于Sham，达到非常显著的程度。在活动组中，服用丁丙诺啡和不服用丁丙诺啡的人在研究期间的饥饿感都有所改善。两组均未发现不良反应。ClinicalTrials.gov标识：NCT04340622。
Background: The opioid epidemic is a global tragedy even with current treatments, and a novel, safe, and effective treatment would be welcomed. We report here our findings from our second randomized controlled trial to evaluate unilateral transcranial photobiomodulation as a treatment for opioid use disorder. Methods: We enrolled 39 participants with active opioid cravings at 2 sites, 19 received the active treatment which consisted of a 4-min twice weekly (every 3 or 4 days) application of a light-emitting diode at 810 nm with an irradiance of 250 mW/cm2 and a fluence of 60 J/cm2 to the forehead over either the left or right dorsolateral prefrontal cortex with a fluence to the brain of 2.1 J/cm2. Twenty participants received a sham treatment with the same device with foil over the bulb. The side of the treatment was based on Dual-Brain Psychology, which posits that one hemisphere is more affected by past maltreatments and is more prone to anxiety and drug cravings that the other hemisphere. We treated the hemisphere with the more positive hemispheric emotional valence (HEV) by 2 tests for HEV. Results: Our primary outcome was changes in pre-treatment opioid craving scale (OCS) minus baseline, and we found using a mixed model that the active group had a highly significant treatment * time benefit over the sham group, p < 0.0001, effect size at the last follow-up of 1.5. The active treatment benefited those not on buprenorphine as well as those not on it. The TimeLine Follow Back measure of opioid use was significantly better in the actively treated group, p = 0.0001, with an effect size of 0.45. We observed no adverse effects. Conclusion: Active unilateral transcranial photobiomodulation to the brain hemisphere with the better HEV was better than sham in the reduction of opioid cravings and opioid use to a very significant degree in a RCT of 39 participants at 2 independent sites. In the active group those on buprenorphine and those not on it both had improvements in cravings over the study. No adverse responses were reported in either group. ClinicalTrials.gov Identifier: NCT04340622.
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DOI：
10.1016/j.bbacli.2016.09.002
发表时间：
2016-12
期刊：
BBA clinical
影响因子：
--
作者：
Hamblin, Michael R
通讯作者：
Hamblin, Michael R
影响因子：
2.4
作者：
Cassano, Paolo;Dording, Christina;Iosifescu, Dan, V
通讯作者：
Iosifescu, Dan, V
DOI：
10.1089/photob.2019.4678
发表时间：
2019-10-01
影响因子：
1.8
作者：
Cassano, Paolo;Caldieraro, Marco Antonio;Iosifescu, Dan V.
通讯作者：
Iosifescu, Dan V.
影响因子：
2.1
作者：
Hwang, Jungyun;Castelli, Darla M.;Gonzalez-Lima, F.
通讯作者：
Gonzalez-Lima, F.
红外线和皮肤：朋友或敌人。
DOI：
10.1016/j.jphotobiol.2015.12.014
发表时间：
2016-02
期刊：
Journal of photochemistry and photobiology. B, Biology
影响因子：
--
作者：
Barolet D;Christiaens F;Hamblin MR
通讯作者：
Hamblin MR