High prevalence of early childhood infection by Kaposi's sarcoma-associated herpesvirus in a minority population in China.
High prevalence of early childhood infection by Kaposi's sarcoma-associated herpesvirus in a minority population in China.
复制标题
卡波西肉瘤相关的疱疹病毒在中国有少数人群中与儿童早期感染的高度流行。
DOI：
10.1111/1469-0691.12340
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Wood C
中科院分区：
文献类型：
--
作者：
Cao Y;Minhas V;Tan X;Huang J;Wang B;Zhu M;Gao Y;Zhao T;Yang L;Wood C
在中国，不同地区和民族的KSHV血清阳性率有很大差异。但在中国西北部的新疆，哈萨克族和维吾尔族成年人中有很高的KSHV血清阳性率。然而，KSHV在儿童中的流行率和与感染相关的风险因素目前尚不清楚。本研究的目的是调查KSHV感染的流行率，确定相关的社会经济或行为危险因素，以及该人群儿童的体液免疫反应。这是一项横断面研究(N=178)，以筛查新疆儿童及其照料者的KSHV总抗体、KSHV中和抗体和HIV感染。采用结构化问卷调查与KSHV流行相关的危险因素。新疆地区儿童和照料者中KSHV血清阳性率分别为48.3%和64.7%。大多数血清阳性的照料者(93.8%)检测到中和抗体，但只有5.8%的感染儿童检测到中和抗体。观察到儿童KSHV血清阳性率与家庭成员分享食物之间存在显著关联。这些结果表明，与非洲其他流行地区相似，新疆少数民族人群中的KSHV感染可能发生在儿童早期，可能通过唾液水平传播，导致成年人群血清阳性率高。
In China, KSHV seroprevalence varies considerably among different regions and ethnicities. But in Xinjiang province, located in the northwestern China, there is a very high seroprevalence of KSHV in adults of Kazak and Ughur ethnicities. However, KSHV prevalence in children and the risk factors associated with the acquisition of infection are currently not known. The aim of this study was to investigate the prevalence of KSHV infection, identify associated socio-economic or behavioral risk factors and the humoral immune response among children in this population. This is a cross-sectional study (N=178) to screen children and their caregivers from Xinjiang for total KSHV antibodies, KSHV neutralizing antibodies and HIV infection. Structured questionnaires were utilized to investigate risk factors associated with KSHV prevalence. KSHV seroprevalence in children and caregivers in Xinjiang was 48.3% and 64.7%, respectively. Neutralizing antibody was detected in most seropositive caregivers (93.8%) but was detected in only 5.8% of the infected children. Significant association was observed between child KSHV seroprevalence and sharing of food among family members. These results suggest that similar to other endemic areas in Africa, KSHV infection in the minority populations of Xinjiang is likely to be occurring during early childhood likely via horizontal transmission through saliva and results to high seroprevalence in the adult population.
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DOI：
10.1111/j.1469-0691.2010.03287.x
发表时间：
2011-03
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Zhang T;He N;Ding Y;Crabtree K;Minhas V;Wood C
通讯作者：
Wood C
影响因子：
158.5
作者：
Cannon, MJ;Dollard, SC;Pellett, PE
通讯作者：
Pellett, PE
影响因子：
6.4
作者：
Blauvelt, A;Sei, S;Jeang, KT
通讯作者：
Jeang, KT
DOI：
10.1080/09540120601114832
发表时间：
2007-07-01
影响因子：
1.7
作者：
Gao, M. Yun;Wang, S.
通讯作者：
Wang, S.
影响因子：
158.5
作者：
Martin, JN;Ganem, DE;Kedes, DH
通讯作者：
Kedes, DH