Sub-chronic administration of fluoxetine does not alter prey-capture or predator avoidance behaviors in adult South African clawed frogs (Xenopus laevis).
Sub-chronic administration of fluoxetine does not alter prey-capture or predator avoidance behaviors in adult South African clawed frogs (Xenopus laevis).
复制标题
亚慢性施用氟西汀不会改变成年南非爪蛙（Xenopus laevis）的捕获猎物或躲避捕食者的行为。
DOI：
10.1016/j.bbr.2023.114317
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发表时间：
2023
影响因子：
2.7
通讯作者：
Carr, James A.
中科院分区：
文献类型：
--
作者：
Menon, Nikhil;Wang, Caoyuanhui;Carr, James A.
动物会停止觅食的努力，并参与防御行为，以回应捕食者的暗示。一些研究人员提出，从食欲到回避行为的转变类似于焦虑，但大多数关于这一点的工作都是在有限数量的动物模型中进行的，主要是斑马鱼和啮齿动物。我们使用成年南非爪蛙（非洲爪蟾），以确定是否典型的抗焦虑药氟西汀改变捕食者引起的食欲和回避行为的变化，在实验室为基础的权衡任务，模仿觅食/捕食者回避权衡在野外。我们假设亚慢性氟西汀治疗（20天）不会影响基线行为，但会逆转捕食者诱导的食物摄入，食欲和回避行为的变化，以及在视顶盖中焦虑相关基因转录的丰度，这是青蛙生态决策的大脑区域。我们发现，氟西汀显着减少基线运动相比，车辆处理的动物。氟西汀对食欲和回避行为没有影响，这些行为在本试验中对捕食者线索敏感，也没有改变顶盖中任何焦虑相关的转录本。我们的结论是，虽然外周亚慢性给药氟西汀显着减少运动，它不修改捕食者引起的变化，在本试验中的方法和回避行为。我们的研究结果是不一致的视觉捕食线索导致状态焦虑的成年青蛙。
Animals will halt foraging efforts and engage defensive behaviors in response to predator cues. Some researchers have proposed that the switch from appetitive to avoidance behavior resembles anxiety, but most work on this has been performed in a limited number of animal models, primarily zebrafish and rodents. We used adult South African clawed frogs (Xenopus laevis) to determine if the canonical anxiolytic fluoxetine alters predator-induced changes in appetitive and avoidance behavior in a laboratory-based trade-off task that mimics foraging/predator avoidance tradeoffs in the wild. We hypothesized that sub-chronic fluoxetine treatment (20 d) would not affect baseline behavior but would reverse predator-induced changes in food intake, appetitive and avoidance behavior, and the abundance of anxiety related gene transcripts in the optic tectum, a brain area central to ecological decision making in frogs. We found that fluoxetine significantly reduced baseline locomotion compared to vehicle-treated animals. Fluoxetine had no effect on appetitive and avoidance behaviors that were sensitive to predator cues in this assay and did not alter any of the anxiety-related transcripts in the tectum. We conclude that while peripheral sub-chronic administration of fluoxetine significantly reduces locomotion, it does not modify predator-induced changes in approach and avoidance behaviors in this assay. Our findings are not consistent with visual predator cues causing state anxiety in adult frogs.
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影响因子：
3.7
作者：
Parker MO;Millington ME;Combe FJ;Brennan CH
通讯作者：
Brennan CH
十字迷宫和趋光性测试不是南非爪蛙焦虑评估的有效行为测定法
DOI：
10.1007/s00359-019-01351-3
发表时间：
2019
期刊：
Journal of Comparative Physiology A
影响因子：
--
作者：
Coleman, R. Boone;Aguirre, Kelsey;Spiegel, Hannah P.;Pecos, Celina;Carr, James A.;Harris, Breanna N.
通讯作者：
Harris, Breanna N.
比较斑马鱼（Danio rerio）多种压力和焦虑测定的行为反应
影响因子：
1.3
作者：
Ryan Y. Wong;Florence Perrin;Sarah E. Oxendine;Zachary D. Kezios;Susanna Sawyer;Linran Zhou;Simone Dereje;J. Godwin
通讯作者：
J. Godwin
氟西汀对斑马鱼的慢性影响：生化和行为的角度
影响因子：
--
作者：
Daniela Correia;Inês Domingues;M. Faria;Miguel Oliveira
通讯作者：
Miguel Oliveira
影响因子：
2.9
作者：
A. Malayev;E. Debski
通讯作者：
E. Debski