Sequence relationships of type D retroviruses which cause simian acquired immunodeficiency syndrome.
Sequence relationships of type D retroviruses which cause simian acquired immunodeficiency syndrome.
复制标题
引起猴获得性免疫缺陷综合征的 D 型逆转录病毒的序列关系。
DOI：
10.1016/0042-6822(87)90274-1
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发表时间：
1987
期刊：
影响因子：
3.7
通讯作者：
Luciw,PA
中科院分区：
文献类型：
--
作者：
Thayer,RM;Power,MD;Bryant,ML;Gardner,MB;Barr,PJ;Luciw,PA
猕猴获得性免疫缺陷综合征（saaids）是由D型逆转录病毒引起的；三个独立的病毒分离株被鉴定为SRV-1 （SAIDS逆转录病毒血清型1）、SRV-2和MPMV （Mason-Pfizer猴病毒）。这三个分离株的病毒粒子具有血清学上相关的核心抗原，但表面蛋白不同。此外，SRV-2是独特的，因为它明显诱导腹膜后纤维瘤病，除了said。本文提出了分子克隆的SRV-2的完整DNA序列，并与SRV-1和MPMV的序列以及真核细胞基因组中其他逆转录病毒和逆转录病毒相关元件的序列进行了比较。SRV-1和MPMV在编码gag、prt、pol和C-terminalenvdomain的预测氨基酸序列上差异小于6%；当与SRV-1或MPMV比对时，SRV-2在这些区域显示出约15-18%的差异。预测的氨基酸序列在位于外部的n端环境域中存在较大的差异；SRV-1和MPMV的同源性为83%，而SRV-2与SRV-1或MPMV的同源性为58%。SRV-1与MPMV的LTRs核苷酸序列同源性为88%；SRV-2与SRV-1和MPMV的ltr具有70%的同源性。将这些类人猿D型逆转录病毒的预测极区氨基酸序列与B型逆转录病毒小鼠乳腺肿瘤病毒（MMTV）的预测极区氨基酸序列进行比较，发现同源性约为50%。一个与MMTV极区相关的人内源性元件与SRV-1或SRV-2的极区氨基酸同源性约为25%。类人猿D型逆转录病毒的基因在大小和预测氨基酸序列上与MMTV和仓鼠内胆A型颗粒基因组相似。禽C型逆转录病毒网状内皮增生病毒（REV）和C型狒狒内源性病毒（BaEV）的C-末端结构域与SRV-1、SRV-2和MPMV的C-末端结构域预测分别具有60%和85%的氨基酸同源性。在类人猿D型逆转录病毒的基因中，有与大鼠的ige结合蛋白基因惊人的同源性。这些D型逆转录病毒与A型、B型和C型逆转录病毒基因组的序列相关性以及与细胞序列的相关性支持了重组事件有助于逆转录病毒发生和变异的观点。这些DNA序列分析也为考虑和比较猿D型逆转录病毒与其他逆转录病毒介导的免疫功能障碍机制提供了依据。
Simian acquired immunodeficiency syndrome (SAIDS) in macaque monkeys is caused by type D retroviruses; three independent virus isolates are identified as SRV-1 (SAIDS retrovirus-serotype 1), SRV-2, and MPMV (Mason-Pfizer monkey virus). Virions from these three isolates have serologically related core antigens, but distinct surface proteins. Also, SRV-2 is unique since it apparently induces retroperitoneal fibromatosis in addition to SAIDS. The complete DNA sequence of molecularly cloned SRV-2 is presented and compared to the sequences of SRV-1 and MPMV and to the sewuences of other retroviruses and retroviral-related elements in the genomes of eucaryotic cells. SRV-1 and MPMV show fewer than 6% differences in predicted amino acid sequences encodinggag, prt, pol, and the C-terminalenvdomain; SRV-2 displays about 15–18% differences in these regions when aligned with SRV-1 or MPMV. Greater variation of predicted amino acid sequences is noted in the externally located N-terminalenvdomains; SRV-1 and MPMV have 83% homology whereas SRV-2 has 58% homology with either SRV-1 or MPMV. Nucleotide sequences of the LTRs of SRV-1 and MPMV are 88% homologous; SRV-2 shows 70% homology with the LTRs of SRV-1 and MPMV. Comparisons of the predictedpolregion amino acid sequences of these simian type D retroviruses with thepolgene of a type B retrovirus, mouse mammary tumor virus (MMTV), reveal about 50% homology. A human endogenous element related to thepolregion of MMTV shows about 25% homology of amino acids with thepolsequences of SRV-1 or SRV-2. Theprtgenes of the simian type D retroviruses are similar in size and predicted amino acid sequence with theprtgenes of MMTV and the hamster intracisternal type A particle genome. The C-terminalenvdomains of the avian type C retrovirus reticuloendotheliosis virus (REV) and the type C baboon endogenous virus (BaEV) have 60 and 85% predicted amino acid homology, respectively, with the C-terminalenvdomains of SRV-1, SRV-2, and MPMV. Within thegagandpolgenes of the simian type D retroviruses there are striking homologies with the rat IgE-binding protein gene. Sequence relatedness of these type D retroviruses with type A, type B, and type C retrovirus genomes and with cellular sequences supports the notion that recombinational events contribute to the genesis and variation of retroviruses. These DNA sequence analyses also provide a basis for considering and comparing mechanisms of immunedysfunction mediated by the simian type D retroviruses and other retroviruses..
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猕猴腹膜后纤维瘤病和获得性免疫缺陷综合征。
DOI：
--
发表时间：
1985
期刊：
The American journal of pathology
影响因子：
--
作者：
GiddensJr,WE;Tsai,CC;Morton,WR;Ochs,HD;Knitter,GH;Blakley,GA
通讯作者：
Blakley,GA
从患有免疫缺陷综合症的猕猴中分离出一种新型 D 型逆转录病毒。
影响因子：
56.9
作者：
Daniel;N. King;Norman L. Letvin;Ronald D. Hunt;P. Sehgal;R. C. Desrosiers
通讯作者：
R. C. Desrosiers
恒河猴自发乳腺肿瘤中的一种新病毒。
影响因子：
11.2
作者：
H. Chopra;M. M. Mason
通讯作者：
M. M. Mason
狒狒内源性逆转录病毒相关成分抑制有丝分裂原诱导的淋巴细胞母细胞生成 1
DOI：
--
发表时间：
1981
期刊：
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
影响因子：
--
作者：
O. Weislow;Oscar U. Fisher;D. Twardzik;A. Hellman;A. Fowler
通讯作者：
A. Fowler
持续感染期间与维斯纳病毒抗原变异相关的基因组变化。
DOI：
--
发表时间：
1980
影响因子：
11.1
作者：
J. Clements;F. Pedersen;O. Narayan;W. Haseltine
通讯作者：
W. Haseltine