Viral and bacterial interactions in the upper respiratory tract.
Viral and bacterial interactions in the upper respiratory tract.
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DOI：
10.1371/journal.ppat.1003057
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发表时间：
2013-01
期刊：
影响因子：
6.7
通讯作者：
Bogaert D
中科院分区：
文献类型：
--
作者：
Bosch AA;Biesbroek G;Trzcinski K;Sanders EA;Bogaert D
呼吸道传染病主要是由经常相互作用的病毒或细菌引起的。虽然病毒和细菌的存在是随后感染的先决条件，但它们可能存在于鼻咽部而不引起任何呼吸道症状。上呼吸道是大量共生菌和潜在致病菌的宿主，形成了一个复杂的微生物群落。这个群落被认为经常受到协同和竞争的种间相互作用的影响。平衡受到干扰，例如由于获得新的细菌或病毒，可能导致过度生长和入侵。更好地了解上呼吸道共生体和病原体之间的动态关系，可以更好地了解呼吸道疾病的发病机制。在这里，我们回顾了目前关于发生在上呼吸道生态位的特定细菌-细菌和病毒-细菌相互作用的知识，并讨论了这些相互作用可能介导的机制。最后，我们提出了一个理论模型来总结和说明这些机制。
Respiratory infectious diseases are mainly caused by viruses or bacteria that often interact with one another. Although their presence is a prerequisite for subsequent infections, viruses and bacteria may be present in the nasopharynx without causing any respiratory symptoms. The upper respiratory tract hosts a vast range of commensals and potential pathogenic bacteria, which form a complex microbial community. This community is assumed to be constantly subject to synergistic and competitive interspecies interactions. Disturbances in the equilibrium, for instance due to the acquisition of new bacteria or viruses, may lead to overgrowth and invasion. A better understanding of the dynamics between commensals and pathogens in the upper respiratory tract may provide better insight into the pathogenesis of respiratory diseases. Here we review the current knowledge regarding specific bacterial–bacterial and viral–bacterial interactions that occur in the upper respiratory niche, and discuss mechanisms by which these interactions might be mediated. Finally, we propose a theoretical model to summarize and illustrate these mechanisms.
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