Low-frequency repetitive transcranial magnetic stimulation (rTMS) affects event-related potential measures of novelty processing in autism.
Low-frequency repetitive transcranial magnetic stimulation (rTMS) affects event-related potential measures of novelty processing in autism.
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DOI：
10.1007/s10484-009-9121-2
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发表时间：
2010-06
影响因子：
3
通讯作者：
Casanova, Manuel F.
中科院分区：
文献类型：
--
作者：
Sokhadze, Estate;Baruth, Joshua;Tasman, Allan;Mansoor, Mehreen;Ramaswamy, Rajesh;Sears, Lonnie;Mathai, Grace;El-Baz, Ayman;Casanova, Manuel F.
关键词：
在我们以前的研究与自闭症谱系障碍（ASD）的个人，我们报告了异常的注意定向额叶事件相关电位（ERP）和持续注意的中央-顶叶ERPs在视觉古怪的实验。这些结果表明，自闭症患者过度处理成功区分目标和新刺激所需的信息。在本研究中，我们研究了低频重复经颅磁刺激（rTMS）对13名ASD患者的新奇处理以及行为和社会功能的影响。我们的假设是，低频rTMS应用于背外侧前额叶皮层（DLFPC）将导致通过激活抑制性GABA能双束中间神经元的皮层兴奋/抑制平衡的改变。我们期望发现TMS后早期和晚期ERP成分的振幅和潜伏期的差异。我们目前的研究结果验证了使用低频rTMS作为调节工具，改变了自闭症患者皮层兴奋与抑制的破坏比例。经颅磁刺激后，顶枕P50的振幅下降到新的分心物，但没有目标，也增加了额叶P50的振幅和潜伏期的目标，而减少非目标刺激。低频rTMS最大限度地减少早期皮层反应无关的刺激和相关刺激的反应增加。在早期皮层反应的选择性改善导致更好的刺激分化在后期的反应是由我们的P3 b和P3 a组件的研究结果明显。这些结果表明，在早期，中潜伏期和晚期ERP组件在额叶，中央顶叶，顶叶和枕叶感兴趣的区域在响应目标和分心刺激的结果，rTMS治疗的显着变化。总体而言，我们的初步结果表明，rTMS可能被证明是一个重要的研究工具或治疗方式，在解决自闭症谱系障碍的刺激超敏反应的特点。
In our previous study on individuals with autism spectrum disorder (ASD) we reported abnormalities in the attention-orienting frontal event-related potentials (ERP) and the sustained-attention centro-parietal ERPs in a visual oddball experiment. These results suggest that individuals with autism over-process information needed for the successful differentiation of target and novel stimuli. In the present study we examine the effects of low-frequency, repetitive Transcranial Magnetic Stimulation (rTMS) on novelty processing as well as behavior and social functioning in 13 individuals with ASD. Our hypothesis was that low-frequency rTMS application to dorsolateral prefrontal cortex (DLFPC) would result in an alteration of the cortical excitatory/inhibitory balance through the activation of inhibitory GABAergic double bouquet interneurons. We expected to find post-TMS differences in amplitude and latency of early and late ERP components. The results of our current study validate the use of low-frequency rTMS as a modulatory tool that altered the disrupted ratio of cortical excitation to inhibition in autism. After rTMS the parieto-occipital P50 amplitude decreased to novel distracters but not to targets; also the amplitude and latency to targets increased for the frontal P50 while decreasing to non-target stimuli. Low-frequency rTMS minimized early cortical responses to irrelevant stimuli and increased responses to relevant stimuli. Improved selectivity in early cortical responses lead to better stimulus differentiation at later-stage responses as was made evident by our P3b and P3a component findings. These results indicate a significant change in early, middle-latency and late ERP components at the frontal, centro-parietal, and parieto-occipital regions of interest in response to target and distracter stimuli as a result of rTMS treatment. Overall, our preliminary results show that rTMS may prove to be an important research tool or treatment modality in addressing the stimulus hypersensitivity characteristic of autism spectrum disorders.
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影响因子：
9.9
作者：
Casanova, MF;Buxhoeveden, DP;Roy, E
通讯作者：
Roy, E
DOI：
10.1016/0013-4694(90)90174-i
发表时间：
1990-03-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
CIESIELSKI, KT;COURCHESNE, E;ELMASIAN, R
通讯作者：
ELMASIAN, R
影响因子：
5.3
作者：
Belmonte, MK;Allen, G;Webb, SJ
通讯作者：
Webb, SJ
影响因子：
11.3
作者：
Boutros, NN;Korzyukov, O;Bell, M
通讯作者：
Bell, M
DOI：
10.1016/s0926-6410(03)00189-7
发表时间：
2003-10-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Belmonte, MK;Yurgelun-Todd, DA
通讯作者：
Yurgelun-Todd, DA