Frequency and Predictors of Traumatic Encephalopathy Syndrome in a Prospective Cohort of Retired Professional Athletes.
Frequency and Predictors of Traumatic Encephalopathy Syndrome in a Prospective Cohort of Retired Professional Athletes.
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DOI：
10.3389/fneur.2021.617526
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发表时间：
2021
影响因子：
3.4
通讯作者：
Cullum CM
中科院分区：
文献类型：
--
作者：
Schaffert J;Didehbani N;LoBue C;Hart J;Rossetti H;Lacritz L;Cullum CM
创伤性脑病综合征（TES）被认为是反复头部损伤暴露的长期影响和慢性创伤性脑病（CTE）的临床表现。本研究旨在评估一组退休专业接触性运动员TES的频率，比较TES的频率与临床共识诊断，并确定增加TES诊断可能性的预测因素。参与者是来自德克萨斯大学西南医学中心和德克萨斯大学达拉斯分校前瞻性队列的85名退休专业接触性运动员。受试者年龄范围为23 - 79岁（M = 55.95，SD = 13.82），受教育年限为7 - 19年（M = 16.08，SD = 1.03）。退休人员为非西班牙裔白色（n = 62）或非洲裔美国人（n = 23）。退役运动员接受了标准的临床评估，其中包括临床访谈，神经系统检查，神经影像学，神经心理学测试，以及正常，轻度认知障碍或痴呆的共识诊断。TES标准适用于所有85名运动员，诊断频率进行了比较。使用二元逻辑回归评估了TES诊断的14个预测因子，包括人口统计学、神经心理学、抑郁症状和头部损伤暴露变量。在这组退役运动员中观察到TES的高频率（56%），但符合TES标准的人中有54%通过共识诊断被诊断为认知正常。在国家橄榄球联盟（OR = 0.993，p = 0.087），脑震荡次数（OR = 1.020，p = 0.532），脑震荡伴意识丧失次数（OR = 1.141，p = 0.188）和职业比赛年数（OR = 0.976，p = 0.627）与TES诊断无关。Beck抑郁量表-II的总评分是TES诊断的唯一预测因子（OR = 1.297，p < 0.001）。我们的研究结果增加了以前的研究结果，强调假阳性诊断的风险，突出了TES标准在临床和研究环境中的局限性，并质疑TES和头部损伤暴露之间的关系。未来的研究需要检查退役职业运动员的抑郁症。
Traumatic encephalopathy syndrome (TES) is proposed to represent the long-term impact of repetitive head-injury exposure and the clinical manifestation of chronic traumatic encephalopathy (CTE). This study aimed to evaluate the frequency of TES in a cohort of retired professional contact sport athletes, compare the frequency of TES to clinical consensus diagnoses, and identify predictors that increase the likelihood of TES diagnosis. Participants were 85 retired professional contact sport athletes from a prospective cohort at the University of Texas Southwestern Medical Center and the University of Texas at Dallas. Participants ranged in age from 23 to 79 (M = 55.95, SD = 13.82) and obtained 7 to 19 years of education (M = 16.08, SD = 1.03). Retirees were either non-Hispanic white (n = 62) or African-American (n = 23). Retired athletes underwent a standard clinical evaluation, which included a clinical interview, neurological exam, neuroimaging, neuropsychological testing, and consensus diagnosis of normal, mild cognitive impairment, or dementia. TES criteria were applied to all 85 athletes, and frequencies of diagnoses were compared. Fourteen predictors of TES diagnosis were evaluated using binary logistic regressions, and included demographic, neuropsychological, depression symptoms, and head-injury exposure variables. A high frequency (56%) of TES was observed among this cohort of retired athletes, but 54% of those meeting criteria for TES were diagnosed as cognitively normal via consensus diagnosis. Games played in the National Football League (OR = 0.993, p = 0.087), number of concussions (OR = 1.020, p = 0.532), number of concussions with loss of consciousness (OR = 1.141 p = 0.188), and years playing professionally (OR = 0.976, p = 0.627) were not associated with TES diagnosis. Degree of depressive symptomatology, as measured by the total score on the Beck Depression Inventory-II, was the only predictor of TES diagnosis (OR = 1.297, p < 0.001). Our results add to previous findings underscoring the risk for false positive diagnosis, highlight the limitations of the TES criteria in clinical and research settings, and question the relationship between TES and head-injury exposure. Future research is needed to examine depression in retired professional athletes.
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DOI：
10.1186/s13195-014-0068-z
发表时间：
2014
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Montenigro PH;Baugh CM;Daneshvar DH;Mez J;Budson AE;Au R;Katz DI;Cantu RC;Stern RA
通讯作者：
Stern RA
影响因子：
2.6
作者：
Fields, Lindy;Didehbani, Nyaz;Cullum, C. Munro
通讯作者：
Cullum, C. Munro
影响因子：
6.8
作者：
Alosco ML;Kasimis AB;Stamm JM;Chua AS;Baugh CM;Daneshvar DH;Robbins CA;Mariani M;Hayden J;Conneely S;Au R;Torres A;McClean MD;McKee AC;Cantu RC;Mez J;Nowinski CJ;Martin BM;Chaisson CE;Tripodis Y;Stern RA
通讯作者：
Stern RA
影响因子：
2.6
作者：
McKee, Ann C.;Alosco, Michael L.;Huber, Bertrand R.
通讯作者：
Huber, Bertrand R.
影响因子：
11.2
作者：
Mez, Jesse;Daneshvar, Daniel H.;McKee, Ann C.
通讯作者：
McKee, Ann C.