Sex differences in benzodiazepine misuse among adults with substance use disorders.
Sex differences in benzodiazepine misuse among adults with substance use disorders.
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DOI：
10.1016/j.addbeh.2020.106608
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发表时间：
2021-01
影响因子：
4.4
通讯作者：
Weiss RD
中科院分区：
文献类型：
--
作者：
McHugh RK;Geyer RB;Chase AR;Griffin ML;Bogunovic O;Weiss RD
女性比男性更有可能被诊断为焦虑症，并被开出苯二氮类药物的处方。有物质使用障碍的人滥用苯二氮卓类药物的风险很高，但对这一人群中苯二氮卓类药物滥用的患病率、相关性或模式的性别差异知之甚少。这项研究的目的是在接受药物使用障碍治疗的成人样本(N=352)中表征苯二氮类药物滥用的性别差异。几乎一半的样本被开了苯二氮卓类药物，超过40%的人滥用了苯二氮卓类药物。女性比男性更有可能拥有终生处方，但并不更有可能报告滥用或经常滥用。与其他物质的数据一致，女性更有可能报告滥用苯二氮卓类药物来应对，并报告更高的焦虑敏感度。绝大多数参与者(97%)报告与其他物质联合使用苯二氮卓类药物，65%的妇女报告通过非口服给药途径(例如鼻内给药)滥用苯二氮卓类药物。虽然苯二氮卓类药物滥用的患病率在男性和女性之间没有实质性差异，但在临床特征和使用方式上发现了一些性别差异。需要进一步研究滥用苯二氮卓类药物的性别差异的性质，以便为患有药物使用障碍的男性和女性提供有针对性的治疗。
Women are more likely than men to be diagnosed with anxiety disorders and to be prescribed benzodiazepines. People with substance use disorders are at a heightened risk for the misuse of benzodiazepines, yet little is known about sex differences in the prevalence, correlates or patterns of benzodiazepine misuse in this population. The aim of this study was to characterize sex differences in benzodiazepine misuse in a sample of adults receiving substance use disorder treatment (N = 352). Almost half of the sample had been prescribed a benzodiazepine and more than 40% had misused a benzodiazepine. Women were more likely to have a lifetime prescription than men, but were not more likely to report misuse or regular misuse. Consistent with data for other substances, women were more likely to report misusing benzodiazepines to cope and reported greater anxiety sensitivity. The vast majority (97%) of participants reported co-use of benzodiazepines with other substances and 65% of women reporting misusing benzodiazepines via a non-oral route of administration (e.g., intranasal). Although benzodiazepine misuse prevalence was not substantively different between men and women, several sex differences in clinical characteristics and patterns of use were identified. Further research on the nature of sex differences in benzodiazepine misuse is needed to inform targeted treatment for both men and women with substance use disorders.
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影响因子：
4.8
作者：
McLean CP;Asnaani A;Litz BT;Hofmann SG
通讯作者：
Hofmann SG
影响因子：
3.9
作者：
McHugh, R. Kathryn;DeVito, Elise E.;Weiss, Roger D.
通讯作者：
Weiss, Roger D.
影响因子：
4.2
作者：
Green, Traci C.;Serrano, Jill M. Grimes;Licari, Andrea;Budman, Simon H.;Butler, Stephen F.
通讯作者：
Butler, Stephen F.
DOI：
10.3109/00952990.2010.535581
发表时间：
2011-01
期刊：
The American journal of drug and alcohol abuse
影响因子：
--
作者：
Hearon BA;Calkins AW;Halperin DM;McHugh RK;Murray HW;Otto MW
通讯作者：
Otto MW
影响因子：
4.2
作者：
Dreifuss, Jessica A.;Griffin, Margaret L.;Weiss, Roger D.
通讯作者：
Weiss, Roger D.