Distinct Antibody Responses to Endemic Coronaviruses Pre- and Post-SARS-CoV-2 Infection in Kenyan Infants and Mothers.
Distinct Antibody Responses to Endemic Coronaviruses Pre- and Post-SARS-CoV-2 Infection in Kenyan Infants and Mothers.
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DOI：
10.3390/v14071517
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发表时间：
2022-07-12
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
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作者：
结合地方性人类冠状病毒（eHCoV）的预先存在的抗体可以与SARS-CoV-2交叉反应，SARS-CoV-2是导致COVID-19的β冠状病毒，但这些反应是否会影响SARS-CoV-2感染仍在调查中，特别是在婴儿中研究不足。在这项研究中，我们测量了肯尼亚妇女及其婴儿在SARS-CoV-2血清转换前后的eHCoV和SARS-CoV-1 IgG抗体滴度。在婴儿或母亲中，预先存在的eHCoV抗体结合滴度与SARS-CoV-2血清转换并不一致;然而，我们观察到预先存在的HCoV-229 E抗体水平与婴儿中缺乏SARS-CoV-2血清转换之间存在非常适度的相关性。在血清转化为SARS-CoV-2后，母亲对地方性β冠状病毒HCoV-OC-43和HCoV-HKU-1以及高致病性β冠状病毒SARS-CoV-1的抗体结合滴度增加，但对地方性β冠状病毒HCoV-229 E和HCoV-NL-63的抗体结合滴度没有增加。然而，在婴儿中SARS-CoV-2血清转化后，eHCoV抗体水平没有增加，这表明在母亲中观察到的增加不仅仅是由于与天然产生的SARS-CoV-2抗体的交叉反应。相比之下，母亲和婴儿在SARS-CoV-2血清转换后，可以结合SARS-CoV-1的抗体水平增加，两者都不太可能有过SARS-CoV-1感染，支持先前的发现，SARS-CoV-2反应与SARS-CoV-1交叉反应。综上所述，我们发现了母亲而不是婴儿在SARS-CoV-2血清转换后eHCoV抗体水平升高的证据，表明当先前的记忆反应已经建立时，SARS-CoV-2感染可以增强eHCoV反应，并且预先存在的交叉反应抗体与母亲或婴儿的SARS-CoV-2感染风险没有强烈相关性。
Pre-existing antibodies that bind endemic human coronaviruses (eHCoVs) can cross-react with SARS-CoV-2, which is the betacoronavirus that causes COVID-19, but whether these responses influence SARS-CoV-2 infection is still under investigation and is particularly understudied in infants. In this study, we measured eHCoV and SARS-CoV-1 IgG antibody titers before and after SARS-CoV-2 seroconversion in a cohort of Kenyan women and their infants. Pre-existing eHCoV antibody binding titers were not consistently associated with SARS-CoV-2 seroconversion in infants or mothers; however, we observed a very modest association between pre-existing HCoV-229E antibody levels and a lack of SARS-CoV-2 seroconversion in the infants. After seroconversion to SARS-CoV-2, antibody binding titers to the endemic betacoronaviruses HCoV-OC43 and HCoV-HKU1, and the highly pathogenic betacoronavirus SARS-CoV-1, but not the endemic alphacoronaviruses HCoV-229E and HCoV-NL63, increased in the mothers. However, eHCoV antibody levels did not increase following SARS-CoV-2 seroconversion in the infants, suggesting the increase seen in the mothers was not simply due to cross-reactivity to naively generated SARS-CoV-2 antibodies. In contrast, the levels of antibodies that could bind SARS-CoV-1 increased after SARS-CoV-2 seroconversion in both the mothers and infants, both of whom were unlikely to have had a prior SARS-CoV-1 infection, supporting prior findings that SARS-CoV-2 responses cross-react with SARS-CoV-1. In summary, we found evidence of increased eHCoV antibody levels following SARS-CoV-2 seroconversion in the mothers but not the infants, suggesting eHCoV responses can be boosted by SARS-CoV-2 infection when a prior memory response has been established, and that pre-existing cross-reactive antibodies are not strongly associated with SARS-CoV-2 infection risk in mothers or infants.
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影响因子：
3.7
作者：
Bonhomme ME;Bonhomme CJ;Strelow L;Chaudhari A;Howlett A;Breidenbach C;Hester J;Hammond C;Fuzy M;Harvey L;Swanner V;Ellis J;Greway RR;Pisciella VA;Green T;Kierstead L
通讯作者：
Kierstead L
影响因子：
30.3
作者：
Lin CY;Wolf J;Brice DC;Sun Y;Locke M;Cherry S;Castellaw AH;Wehenkel M;Crawford JC;Zarnitsyna VI;Duque D;Allison KJ;Allen EK;Brown SA;Mandarano AH;Estepp JH;SJTRC Study Team;Taylor C;Molina-Paris C;Schultz-Cherry S;Tang L;Thomas PG;McGargill MA
通讯作者：
McGargill MA
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1093/infdis/jiaa691
发表时间：
2021-02-13
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Goldstein E;Lipsitch M;Cevik M
通讯作者：
Cevik M
DOI：
10.1016/j.ijid.2020.10.104
发表时间：
2021-01
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Tso FY;Lidenge SJ;Peña PB;Clegg AA;Ngowi JR;Mwaiselage J;Ngalamika O;Julius P;West JT;Wood C
通讯作者：
Wood C