Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat.
Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat.
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DOI：
10.1155/2018/5903720
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发表时间：
2018
影响因子：
3.1
通讯作者：
Syka J
中科院分区：
文献类型：
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作者：
Bureš Z;Pysanenko K;Lindovský J;Syka J
众所周知，在早期发育期间的听觉经验塑造听觉皮层（AC）神经元的响应特性，影响例如音调排列、响应阈值和强度或频率选择性。在这里，我们表明，饲养大鼠幼崽在一个复杂的声学丰富的环境中导致AC神经元的反应的可靠性增加，影响率和时间代码。对于重复刺激，神经元表现出较低的尖峰计数方差，表明更稳定的速率编码。在单个尖峰的水平上，单个神经元的放电模式在刺激重复中表现出更高程度的相似性。此外，神经元更精确地跟随刺激的时间过程，如通过改善对时间调制的声音的锁相所表现的。这些变化是持续的，一直持续到成年。结果表明，除了在我们以前的研究中提出的感受野的基本改变，出生后发育的关键时期的声环境也会导致神经元尖峰模式的随机性降低和再现性提高。
It is well known that auditory experience during early development shapes response properties of auditory cortex (AC) neurons, influencing, for example, tonotopical arrangement, response thresholds and strength, or frequency selectivity. Here, we show that rearing rat pups in a complex acoustically enriched environment leads to an increased reliability of responses of AC neurons, affecting both the rate and the temporal codes. For a repetitive stimulus, the neurons exhibit a lower spike count variance, indicating a more stable rate coding. At the level of individual spikes, the discharge patterns of individual neurons show a higher degree of similarity across stimulus repetitions. Furthermore, the neurons follow more precisely the temporal course of the stimulus, as manifested by improved phase-locking to temporally modulated sounds. The changes are persistent and present up to adulthood. The results document that besides basic alterations of receptive fields presented in our previous study, the acoustic environment during the critical period of postnatal development also leads to a decreased stochasticity and a higher reproducibility of neuronal spiking patterns.
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环境丰富可以挽救早期噪声暴露引起的皮质神经元听觉时间分辨率下降
影响因子：
3.4
作者：
Jiang, Cuiping;Xu, Xiaoxiao;Zhang, Jiping
通讯作者：
Zhang, Jiping
影响因子：
2.8
作者：
Bures, Zbynek;Popelar, Jiri;Syka, Josef
通讯作者：
Syka, Josef
影响因子：
2.9
作者：
Bures, Zbynek;Marsalek, Petr
通讯作者：
Marsalek, Petr
影响因子：
25
作者：
de Villers-Sidani, Etienne;Simpson, Kimberly L.;Lu, Y-F;Lin, Rick C. S.;Merzenich, Michael M.
通讯作者：
Merzenich, Michael M.
影响因子：
64.8
作者：
通讯作者：
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