Virus-induced neurobehavioral disorders: mechanisms and implications.

Virus-induced neurobehavioral disorders: mechanisms and implications.
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DOI:
10.1016/j.molmed.2003.12.001
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发表时间:
2004-02
影响因子:
13.6
通讯作者:
Tomonaga K
Tomonaga K
中科院分区:
医学1区
文献类型:
--
作者:
Tomonaga K

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神经精神疾病的病因学的一个假说提出,病毒感染有助于诱导神经系统功能障碍,导致广泛的行为异常。最近的分子生物学研究支持这一假设,并重新关注病毒感染在精神疾病发展中的作用。病毒感染可通过直接和/或间接途径在中枢神经系统中诱导有害作用。了解持续病毒感染引起的神经胶质细胞功能障碍的机制,将导致对神经行为障碍(包括人类精神疾病)发展的新见解,并可能发展治疗方法。
One hypothesis for the etiology of neuropsychiatric disorders proposes that viral infection contributes to the induction of neuronal system dysfunction, resulting in a wide range of behavioral abnormalities. Recent research in molecular biology supports this hypothesis and refocuses on the role of viral infection in the development of psychiatric disorders. Viral infection can induce deleterious effects in the central nervous system by direct and/or indirect pathways. Understanding the mechanisms of glial cell dysfunction caused by persistent viral infection should lead to novel insights into the development of neurobehavioral disorders, including human mental illnesses, and to the possible development of treatments.
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